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Peptide record

TPDB47057

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47057
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
GKKVLQ
Physicochemical Analysis
C30H57N9O8
ARNDCEHIMFPSTWY
K
671.84
10.60
2
0
2
+2
2.08
-0.617
113.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
6
C30H57N9O8
671.84
10.60
+2
2.08
-0.617
671.8268
671.4317
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.90 µM
ACE inhibitor
ah

Source & Reference

NA
Mito K., Fujii M., Kuwahara M., Matsumura N., Shimizu T., Sugano S., Karaki H.
Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from hemoglobin. Eur. J. Pharmacol., 304, 93-98
1996
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCCCN)NC(=O)CN)C(C)C)C(O)=O InChI=1S/C30H57N9O8/c1-17(2)15-22(28(44)37-21(30(46)47)11-12-23(34)40)38-29(45)25(18(3)4)39-27(43)20(10-6-8-14-32)36-26(42)19(9-5-7-13-31)35-24(41)16-33/h17-22,25H,5-16,31-33H2,1-4H3,(H2,34,40)(H,35,41)(H,36,42)(H,37,44)(H,38,45)(H,39,43)(H,46,47)/t19-,20-,21-,22-,25-/m0/s1 InChIKey=ZLRYLMJEBRBCHY-XHVFSLISSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
1.90 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Mito K., Fujii M., Kuwahara M., Matsumura N., Shimizu T., Sugano S., Karaki H.
Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from hemoglobin. Eur. J. Pharmacol., 304, 93-98
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCCCN)NC(=O)CN)C(C)C)C(O)=O InChI=1S/C30H57N9O8/c1-17(2)15-22(28(44)37-21(30(46)47)11-12-23(34)40)38-29(45)25(18(3)4)39-27(43)20(10-6-8-14-32)36-26(42)19(9-5-7-13-31)35-24(41)16-33/h17-22,25H,5-16,31-33H2,1-4H3,(H2,34,40)(H,35,41)(H,36,42)(H,37,44)(H,38,45)(H,39,43)(H,46,47)/t19-,20-,21-,22-,25-/m0/s1 InChIKey=ZLRYLMJEBRBCHY-XHVFSLISSA-N
Additional Detail Fields 1 fields
6