TPDB

3D PDB MODEL

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TPDB ID TPDB47052

Peptide_Name

ACE Inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

GGVIPN

FASTA

>TPDB47052|ACE inhibitors;Antihypertensive|length=6
GGVIPN

Formula C24H41N7O8

Absent Amino Acids ARDCEQHLKMFSTWY

Common Amino Acids G

Mass 555.63

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index 0.65

Hydrophobicity 0.467

Aliphatic Index 113.33

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

2

G

0

H

1

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

6

Formula

C24H41N7O8

Mass

555.63

PI

6.02

Net Charge

-0

Boman Index

0.65

Hydrophobicity

0.467

Chemical_Mass

555.6228

Monoisotopic_Mass

555.3007

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.74 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Matsui T., Li C.-H., Osajima Y.

Title

Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ. J. Peptide Sci., 5, 289-297, 1999

Year 1999

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)O InChI=1S/C24H41N7O8/c1-5-13(4)20(30-22(36)19(12(2)3)29-18(34)11-27-17(33)10-25)23(37)31-8-6-7-15(31)21(35)28-14(24(38)39)9-16(26)32/h12-15,19-20H,5-11,25H2,1-4H3,(H2,26,32)(H,27,33)(H,28,35)(H,29,34)(H,30,36)(H,38,39)/t13-,14-,15-,19-,20-/m0/s1 InChIKey: LKNOHWMJXPKAHT-QEFISFJRSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.74 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Matsui T., Li C.-H., Osajima Y.

Title

Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ. J. Peptide Sci., 5, 289-297, 1999

Year 1999

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)O InChI=1S/C24H41N7O8/c1-5-13(4)20(30-22(36)19(12(2)3)29-18(34)11-27-17(33)10-25)23(37)31-8-6-7-15(31)21(35)28-14(24(38)39)9-16(26)32/h12-15,19-20H,5-11,25H2,1-4H3,(H2,26,32)(H,27,33)(H,28,35)(H,29,34)(H,30,36)(H,38,39)/t13-,14-,15-,19-,20-/m0/s1 InChIKey: LKNOHWMJXPKAHT-QEFISFJRSA-N

Number_of_Residues

6