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Peptide record

TPDB47031

ACE Inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47031
ACE Inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
YYAPFDGIL
Physicochemical Analysis
C53H71N9O14
RNCEQHKMSTWV
Y
1058.20
3.10
0
1
6
-1
-2.36
0.533
97.78
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
281.61
2
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
9
C53H71N9O14
1058.20
3.10
-1
-2.36
0.533
1058.1799
1057.5103
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
83.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Takayanagi T., Yokotsuka K.
Angiotensin I converting enzyme-inhibitory peptides from wine. Am. J. Enol. Viticult., 50, 65-68, 1999
1999
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](C)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C53H71N9O14/c1-6-30(4)45(51(73)60-41(53(75)76)23-29(2)3)61-43(65)28-55-47(69)40(27-44(66)67)58-49(71)39(25-32-11-8-7-9-12-32)59-50(72)42-13-10-22-62(42)52(74)31(5)56-48(70)38(26-34-16-20-36(64)21-17-34)57-46(68)37(54)24-33-14-18-35(63)19-15-33/h7-9,11-12,14-21,29-31,37-42,45,63-64H,6,10,13,22-28,54H2,1-5H3,(H,55,69)(H,56,70)(H,57,68)(H,58,71)(H,59,72)(H,60,73)(H,61,65)(H,66,67)(H,75,76)/t30-,31-,37-,38-,39-,40-,41-,42-,45-/m0/s1 InChIKey: KXTNTVZHPOVOND-IGQOJWJDSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
83.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Takayanagi T., Yokotsuka K.
Angiotensin I converting enzyme-inhibitory peptides from wine. Am. J. Enol. Viticult., 50, 65-68, 1999
1999
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](C)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C53H71N9O14/c1-6-30(4)45(51(73)60-41(53(75)76)23-29(2)3)61-43(65)28-55-47(69)40(27-44(66)67)58-49(71)39(25-32-11-8-7-9-12-32)59-50(72)42-13-10-22-62(42)52(74)31(5)56-48(70)38(26-34-16-20-36(64)21-17-34)57-46(68)37(54)24-33-14-18-35(63)19-15-33/h7-9,11-12,14-21,29-31,37-42,45,63-64H,6,10,13,22-28,54H2,1-5H3,(H,55,69)(H,56,70)(H,57,68)(H,58,71)(H,59,72)(H,60,73)(H,61,65)(H,66,67)(H,75,76)/t30-,31-,37-,38-,39-,40-,41-,42-,45-/m0/s1 InChIKey: KXTNTVZHPOVOND-IGQOJWJDSA-N
Additional Detail Fields 1 fields
9