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Peptide record

TPDB47002

ACE inhibitor from alphas2-CN (92-98) ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47002
ACE inhibitor from alphas2-CN (92-98)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
FPQYLQY
Physicochemical Analysis
C48H63N9O12
ARNDCEGHIKMSTWV
QY
958.08
5.88
0
0
4
-0
-1.96
-0.657
55.71
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
2980
311.04
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
7
C48H63N9O12
958.08
5.88
-0
-1.96
-0.657
958.0644
957.4581
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
14.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tauzin J., Miclo L., Gaillard J. L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alphaS2-casein. FEBS Lett., 531, 369-374, 2002
2002
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O InChI=1S/C48H63N9O12/c1-27(2)23-36(44(64)52-34(18-20-40(50)60)43(63)56-38(48(68)69)26-30-12-16-32(59)17-13-30)54-45(65)37(25-29-10-14-31(58)15-11-29)55-42(62)35(19-21-41(51)61)53-46(66)39-9-6-22-57(39)47(67)33(49)24-28-7-4-3-5-8-28/h3-5,7-8,10-17,27,33-39,58-59H,6,9,18-26,49H2,1-2H3,(H2,50,60)(H2,51,61)(H,52,64)(H,53,66)(H,54,65)(H,55,62)(H,56,63)(H,68,69)/t33-,34-,35-,36-,37-,38-,39-/m0/s1 InChIKey=VKSNJBLEWNYDPF-ZTYVOHGWSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
14.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tauzin J., Miclo L., Gaillard J. L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alphaS2-casein. FEBS Lett., 531, 369-374, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O InChI=1S/C48H63N9O12/c1-27(2)23-36(44(64)52-34(18-20-40(50)60)43(63)56-38(48(68)69)26-30-12-16-32(59)17-13-30)54-45(65)37(25-29-10-14-31(58)15-11-29)55-42(62)35(19-21-41(51)61)53-46(66)39-9-6-22-57(39)47(67)33(49)24-28-7-4-3-5-8-28/h3-5,7-8,10-17,27,33-39,58-59H,6,9,18-26,49H2,1-2H3,(H2,50,60)(H2,51,61)(H,52,64)(H,53,66)(H,54,65)(H,55,62)(H,56,63)(H,68,69)/t33-,34-,35-,36-,37-,38-,39-/m0/s1 InChIKey=VKSNJBLEWNYDPF-ZTYVOHGWSA-N
Additional Detail Fields 1 fields
7