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Peptide record

TPDB46996

190-197) ACE inhibitor (as2-casein fragment ACE inhibitors Antihypertensive Neuropeptide standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB46996
190-197) ACE inhibitor (as2-casein fragment
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
MKPWIQPK
Physicochemical Analysis
C49H78N12O10S1
ARNDCEGHLFSTYV
KP
1027.29
10.60
2
0
3
+2
1.07
-1.125
48.75
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
535.39
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
2
K
1
M
0
F
2
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 2 M: 1 F: 0 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
8
C49H78N12O10S1
1027.29
10.60
+2
1.07
-1.125
1027.2810
1026.5667
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
300.00 µM
ACE inhibitor
ah

Source & Reference

FermFooDB
Maeno M., Yamamoto N., Takano T.
Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 79,1316-1321
1996
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C49H78N12O10S/c1-4-29(2)41(46(67)56-35(19-20-40(53)62)48(69)61-25-11-17-38(61)44(65)57-36(49(70)71)16-8-10-23-51)59-43(64)37(27-30-28-54-33-14-6-5-13-31(30)33)58-45(66)39-18-12-24-60(39)47(68)34(15-7-9-22-50)55-42(63)32(52)21-26-72-3/h5-6,13-14,28-29,32,34-39,41,54H,4,7-12,15-27,50-52H2,1-3H3,(H2,53,62)(H,55,63)(H,56,67)(H,57,65)(H,58,66)(H,59,64)(H,70,71)/t29-,32-,34-,35-,36-,37-,38-,39-,41-/m0/s1 InChIKey=WLFZUYNAZUILDK-VJEMLBLASA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
300.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Maeno M., Yamamoto N., Takano T.
Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 79,1316-1321
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C49H78N12O10S/c1-4-29(2)41(46(67)56-35(19-20-40(53)62)48(69)61-25-11-17-38(61)44(65)57-36(49(70)71)16-8-10-23-51)59-43(64)37(27-30-28-54-33-14-6-5-13-31(30)33)58-45(66)39-18-12-24-60(39)47(68)34(15-7-9-22-50)55-42(63)32(52)21-26-72-3/h5-6,13-14,28-29,32,34-39,41,54H,4,7-12,15-27,50-52H2,1-3H3,(H2,53,62)(H,55,63)(H,56,67)(H,57,65)(H,58,66)(H,59,64)(H,70,71)/t29-,32-,34-,35-,36-,37-,38-,39-,41-/m0/s1 InChIKey=WLFZUYNAZUILDK-VJEMLBLASA-N
Additional Detail Fields 1 fields
8