TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB46991

Peptide_Name

ACE inhibitor Hypotensive peptide

Activity

ACE inhibitors Antihypertensive Neuropeptide iDPPIV

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides

Database_Source

FermFooDB pep-lab Peptipedia AHTPDB AHTpin iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Neuropeptide, and other sources) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.

Sequence

LHLPLPL

FASTA

>TPDB46991|ACE inhibitors;Antihypertensive;Neuropeptide;iDPPIV|length=7
LHLPLPL

Formula C40H67N9O8

Absent Amino Acids ARNDCEQGIKMFSTWYV

Common Amino Acids L

Mass 802.03

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +0

Boman Index -0.38

Hydrophobicity 1.257

Aliphatic Index 222.86

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

4

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 4 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C40H67N9O8

Mass

802.03

PI

7.85

Net Charge

+0

Boman Index

-0.38

Hydrophobicity

1.257

Chemical_Mass

802.0128

Monoisotopic_Mass

801.5097

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 432.70 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source FermFooDB

Authors Miguel M., Recio I., Ramos M., Delgado M. A., Aleixandre M. A.

Title

Antihypertensive effect of peptides obtained from Enterococcus faecalis-fermented milk in rats. J. Dairy Sci., 89, 3352-3359, 2006

Year 2006

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC(C)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC(C)C)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C40H67N9O8/c1-22(2)15-27(41)34(50)44-28(19-26-20-42-21-43-26)35(51)45-29(16-23(3)4)38(54)48-13-9-11-32(48)36(52)46-30(17-24(5)6)39(55)49-14-10-12-33(49)37(53)47-31(40(56)57)18-25(7)8/h20-25,27-33H,9-19,41H2,1-8H3,(H,42,43)(H,44,50)(H,45,51)(H,46,52)(H,47,53)(H,56,57)/t27-,28-,29-,30-,31-,32-,33-/m0/s1 InChIKey=YYTXSZFDTAQSBA-MRNVWEPHSA-N Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10078) the EROP-Moscow database

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 432.70 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB FermFooDB

Authors Miguel M., Recio I., Ramos M., Delgado M. A., Aleixandre M. A.

Title

Antihypertensive effect of peptides obtained from Enterococcus faecalis-fermented milk in rats. J. Dairy Sci., 89, 3352-3359, 2006

Year 2006

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC(C)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC(C)C)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C40H67N9O8/c1-22(2)15-27(41)34(50)44-28(19-26-20-42-21-43-26)35(51)45-29(16-23(3)4)38(54)48-13-9-11-32(48)36(52)46-30(17-24(5)6)39(55)49-14-10-12-33(49)37(53)47-31(40(56)57)18-25(7)8/h20-25,27-33H,9-19,41H2,1-8H3,(H,42,43)(H,44,50)(H,45,51)(H,46,52)(H,47,53)(H,56,57)/t27-,28-,29-,30-,31-,32-,33-/m0/s1 InChIKey=YYTXSZFDTAQSBA-MRNVWEPHSA-N Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10078) the EROP-Moscow database

Evidence 3 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Lowering blood pressure in rats

Detail Activity hypotensive

Activity Code hyp

Source & Reference

Database Source AHTPDB FermFooDB

Authors Miguel M., Recio I., Ramos M., Delgado M. A., Aleixandre M. A.

Title

Antihypertensive effect of peptides obtained from Enterococcus faecalis-fermented milk in rats. J. Dairy Sci., 89, 3352-3359, 2006

Year 2006

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC(C)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC(C)C)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C40H67N9O8/c1-22(2)15-27(41)34(50)44-28(19-26-20-42-21-43-26)35(51)45-29(16-23(3)4)38(54)48-13-9-11-32(48)36(52)46-30(17-24(5)6)39(55)49-14-10-12-33(49)37(53)47-31(40(56)57)18-25(7)8/h20-25,27-33H,9-19,41H2,1-8H3,(H,42,43)(H,44,50)(H,45,51)(H,46,52)(H,47,53)(H,56,57)/t27-,28-,29-,30-,31-,32-,33-/m0/s1 InChIKey=YYTXSZFDTAQSBA-MRNVWEPHSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 7565) the EROP-Moscow database the MBPDB database

Number_of_Residues

7