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Peptide record

TPDB46990

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide iDPPIV standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB46990
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Neuropeptide, and other sources) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LHLPLP
Physicochemical Analysis
C34H56N8O7
ARNDCEQGIKMFSTWYV
L
688.87
7.85
1
0
3
+0
0.18
0.833
195.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
3
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 3 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C34H56N8O7
688.87
7.85
+0
0.18
0.833
688.8556
688.4259
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C34H56N8O7/c1-19(2)13-23(35)29(43)38-24(16-22-17-36-18-37-22)30(44)39-25(14-20(3)4)32(46)41-11-7-9-27(41)31(45)40-26(15-21(5)6)33(47)42-12-8-10-28(42)34(48)49/h17-21,23-28H,7-16,35H2,1-6H3,(H,36,37)(H,38,43)(H,39,44)(H,40,45)(H,48,49)/t23-,24-,25-,26-,27-,28-/m0/s1 InChIKey: QLFCYFCBEUPIBA-QUQVWLGBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Another value of peptide IC50(EC50)=5,5uM. Hernández-Ledesma B., Quirós A., Amigo L., Recio I., 2007, Identification of bioactive peptides after digestion of human milk and infant formula with pepsin and pancreatin. Int. Dairy J., 17, 42-49
Evidence 2 Activity

Activity

IC50
Antihypertensive
2.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C34H56N8O7/c1-19(2)13-23(35)29(43)38-24(16-22-17-36-18-37-22)30(44)39-25(14-20(3)4)32(46)41-11-7-9-27(41)31(45)40-26(15-21(5)6)33(47)42-12-8-10-28(42)34(48)49/h17-21,23-28H,7-16,35H2,1-6H3,(H,36,37)(H,38,43)(H,39,44)(H,40,45)(H,48,49)/t23-,24-,25-,26-,27-,28-/m0/s1 InChIKey: QLFCYFCBEUPIBA-QUQVWLGBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Another value of peptide IC50(EC50)=5,5uM. Hernández-Ledesma B., Quirós A., Amigo L., Recio I., 2007, Identification of bioactive peptides after digestion of human milk and infant formula with pepsin and pancreatin. Int. Dairy J., 17, 42-49
Additional Detail Fields 1 fields
6