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Peptide record

TPDB46985

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB46985
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VPSERYL
Physicochemical Analysis
C39H62N10O12
ANDCQGHIKMFTW
RELPSYV
862.98
6.90
1
1
3
-0
1.98
-0.529
97.14
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
172.66
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
7
C39H62N10O12
862.98
6.90
-0
1.98
-0.529
862.9669
862.4534
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
232.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Sieber R., Bütikofer U., Egger C., Portmann R., Walther B., Weschsler D.
ACE-inhibitory activity and ACE-inhibiting peptides in different cheese varieties. Dairy Sci. Technol., 2010, 90:47-73.
2010
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C39H62N10O12/c1-20(2)17-27(38(60)61)47-34(56)26(18-22-9-11-23(51)12-10-22)46-32(54)24(7-5-15-43-39(41)42)44-33(55)25(13-14-30(52)53)45-35(57)28(19-50)48-36(58)29-8-6-16-49(29)37(59)31(40)21(3)4/h9-12,20-21,24-29,31,50-51H,5-8,13-19,40H2,1-4H3,(H,44,55)(H,45,57)(H,46,54)(H,47,56)(H,48,58)(H,52,53)(H,60,61)(H4,41,42,43)/t24-,25-,26-,27-,28-,29-,31-/m0/s1 InChIKey: VTSANRNVZZOBGM-IRQHXVELSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
232.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Sieber R., Bütikofer U., Egger C., Portmann R., Walther B., Weschsler D.
ACE-inhibitory activity and ACE-inhibiting peptides in different cheese varieties. Dairy Sci. Technol., 2010, 90:47-73.
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C39H62N10O12/c1-20(2)17-27(38(60)61)47-34(56)26(18-22-9-11-23(51)12-10-22)46-32(54)24(7-5-15-43-39(41)42)44-33(55)25(13-14-30(52)53)45-35(57)28(19-50)48-36(58)29-8-6-16-49(29)37(59)31(40)21(3)4/h9-12,20-21,24-29,31,50-51H,5-8,13-19,40H2,1-4H3,(H,44,55)(H,45,57)(H,46,54)(H,47,56)(H,48,58)(H,52,53)(H,60,61)(H4,41,42,43)/t24-,25-,26-,27-,28-,29-,31-/m0/s1 InChIKey: VTSANRNVZZOBGM-IRQHXVELSA-N
Additional Detail Fields 1 fields
7