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Peptide record

TPDB46980

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB46980
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
DKVGINYW
Physicochemical Analysis
C47H67N11O13
ARCEQHLMFPST
NDGIKWYV
994.11
6.68
1
1
4
-0
-0.38
-0.600
85.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
6990
703.14
2
Residue Composition
number
0
A
0
R
1
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
8
C47H67N11O13
994.11
6.68
-0
-0.38
-0.600
994.0981
993.4904
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
25.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c2ccccc2[nH]c1)C(=O)O InChI=1S/C47H67N11O13/c1-5-25(4)40(57-37(61)23-52-45(68)39(24(2)3)58-42(65)32(12-8-9-17-48)53-41(64)30(49)20-38(62)63)46(69)55-34(21-36(50)60)44(67)54-33(18-26-13-15-28(59)16-14-26)43(66)56-35(47(70)71)19-27-22-51-31-11-7-6-10-29(27)31/h6-7,10-11,13-16,22,24-25,30,32-35,39-40,51,59H,5,8-9,12,17-21,23,48-49H2,1-4H3,(H2,50,60)(H,52,68)(H,53,64)(H,54,67)(H,55,69)(H,56,66)(H,57,61)(H,58,65)(H,62,63)(H,70,71)/t25-,30-,32-,33-,34-,35-,39-,40-/m0/s1 InChIKey: GFTYIRTWZKCKBT-LCTCTEIDSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
25.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c2ccccc2[nH]c1)C(=O)O InChI=1S/C47H67N11O13/c1-5-25(4)40(57-37(61)23-52-45(68)39(24(2)3)58-42(65)32(12-8-9-17-48)53-41(64)30(49)20-38(62)63)46(69)55-34(21-36(50)60)44(67)54-33(18-26-13-15-28(59)16-14-26)43(66)56-35(47(70)71)19-27-22-51-31-11-7-6-10-29(27)31/h6-7,10-11,13-16,22,24-25,30,32-35,39-40,51,59H,5,8-9,12,17-21,23,48-49H2,1-4H3,(H2,50,60)(H,52,68)(H,53,64)(H,54,67)(H,55,69)(H,56,66)(H,57,61)(H,58,65)(H,62,63)(H,70,71)/t25-,30-,32-,33-,34-,35-,39-,40-/m0/s1 InChIKey: GFTYIRTWZKCKBT-LCTCTEIDSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
8