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Peptide record

TPDB46979

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB46979
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
DKVGINY
Physicochemical Analysis
C36H57N9O12
ARCEQHLMFPSTW
NDGIKYV
807.90
6.68
1
1
3
-0
1.47
-0.557
97.14
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1490
184.43
2
Residue Composition
number
0
A
0
R
1
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
7
C36H57N9O12
807.90
6.68
-0
1.47
-0.557
807.8886
807.4113
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
84.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O InChI=1S/C36H57N9O12/c1-5-19(4)30(35(55)42-24(16-26(39)47)33(53)43-25(36(56)57)14-20-9-11-21(46)12-10-20)44-27(48)17-40-34(54)29(18(2)3)45-32(52)23(8-6-7-13-37)41-31(51)22(38)15-28(49)50/h9-12,18-19,22-25,29-30,46H,5-8,13-17,37-38H2,1-4H3,(H2,39,47)(H,40,54)(H,41,51)(H,42,55)(H,43,53)(H,44,48)(H,45,52)(H,49,50)(H,56,57)/t19-,22-,23-,24-,25-,29-,30-/m0/s1 InChIKey: ZVESKUBHZIBSKD-QNUQHRJKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
84.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O InChI=1S/C36H57N9O12/c1-5-19(4)30(35(55)42-24(16-26(39)47)33(53)43-25(36(56)57)14-20-9-11-21(46)12-10-20)44-27(48)17-40-34(54)29(18(2)3)45-32(52)23(8-6-7-13-37)41-31(51)22(38)15-28(49)50/h9-12,18-19,22-25,29-30,46H,5-8,13-17,37-38H2,1-4H3,(H2,39,47)(H,40,54)(H,41,51)(H,42,55)(H,43,53)(H,44,48)(H,45,52)(H,49,50)(H,56,57)/t19-,22-,23-,24-,25-,29-,30-/m0/s1 InChIKey: ZVESKUBHZIBSKD-QNUQHRJKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7