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Peptide record

TPDB46978

ACE inhibitor ACE inhibitors Antihypertensive standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB46978
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 11-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
KGYGGVSLPEW
Physicochemical Analysis
C56H81N13O16
ARNDCQHIMFT
G
1192.34
6.87
1
1
4
-0
0.34
-0.473
61.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
586.24
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
3
G
0
H
0
I
1
L
1
K
0
M
0
F
1
P
1
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
11
C56H81N13O16
1192.34
6.87
-0
0.34
-0.473
1192.3166
1191.5905
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

11
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)O InChI=1S/C56H81N13O16/c1-30(2)22-40(55(83)69-21-9-13-43(69)53(81)64-38(18-19-47(75)76)51(79)66-41(56(84)85)24-33-25-59-37-12-6-5-10-35(33)37)65-52(80)42(29-70)67-54(82)48(31(3)4)68-46(74)27-60-44(72)26-62-50(78)39(23-32-14-16-34(71)17-15-32)63-45(73)28-61-49(77)36(58)11-7-8-20-57/h5-6,10,12,14-17,25,30-31,36,38-43,48,59,70-71H,7-9,11,13,18-24,26-29,57-58H2,1-4H3,(H,60,72)(H,61,77)(H,62,78)(H,63,73)(H,64,81)(H,65,80)(H,66,79)(H,67,82)(H,68,74)(H,75,76)(H,84,85)/t36-,38-,39-,40-,41-,42-,43-,48-/m0/s1 InChIKey: XGDNJXQHKBBJBC-HGOVXFOSSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
11
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)O InChI=1S/C56H81N13O16/c1-30(2)22-40(55(83)69-21-9-13-43(69)53(81)64-38(18-19-47(75)76)51(79)66-41(56(84)85)24-33-25-59-37-12-6-5-10-35(33)37)65-52(80)42(29-70)67-54(82)48(31(3)4)68-46(74)27-60-44(72)26-62-50(78)39(23-32-14-16-34(71)17-15-32)63-45(73)28-61-49(77)36(58)11-7-8-20-57/h5-6,10,12,14-17,25,30-31,36,38-43,48,59,70-71H,7-9,11,13,18-24,26-29,57-58H2,1-4H3,(H,60,72)(H,61,77)(H,62,78)(H,63,73)(H,64,81)(H,65,80)(H,66,79)(H,67,82)(H,68,74)(H,75,76)(H,84,85)/t36-,38-,39-,40-,41-,42-,43-,48-/m0/s1 InChIKey: XGDNJXQHKBBJBC-HGOVXFOSSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
11