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Peptide record

TPDB46977

ACE inhibitor ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB46977
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
DAQSAPLRVY
Physicochemical Analysis
C49H78N14O16
NCEGHIKMFTW
A
1119.24
6.71
1
1
5
-0
1.43
-0.360
88.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1490
133.13
3
Residue Composition
number
2
A
1
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
10
C49H78N14O16
1119.24
6.71
-0
1.43
-0.360
1119.2247
1118.5702
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
13.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C49H78N14O16/c1-23(2)19-32(43(73)58-30(9-7-17-54-49(52)53)42(72)62-38(24(3)4)46(76)60-33(48(78)79)20-27-11-13-28(65)14-12-27)59-45(75)35-10-8-18-63(35)47(77)26(6)56-44(74)34(22-64)61-41(71)31(15-16-36(51)66)57-39(69)25(5)55-40(70)29(50)21-37(67)68/h11-14,23-26,29-35,38,64-65H,7-10,15-22,50H2,1-6H3,(H2,51,66)(H,55,70)(H,56,74)(H,57,69)(H,58,73)(H,59,75)(H,60,76)(H,61,71)(H,62,72)(H,67,68)(H,78,79)(H4,52,53,54)/t25-,26-,29-,30-,31-,32-,33-,34-,35-,38-/m0/s1 InChIKey: OVZGOCMQQXSJSD-UQIDJKEMSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
13.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tavares T., del Mar Contreras M., Amorim M., Pintado M., Recio I., Malcata F. X.
Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013-1019, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C49H78N14O16/c1-23(2)19-32(43(73)58-30(9-7-17-54-49(52)53)42(72)62-38(24(3)4)46(76)60-33(48(78)79)20-27-11-13-28(65)14-12-27)59-45(75)35-10-8-18-63(35)47(77)26(6)56-44(74)34(22-64)61-41(71)31(15-16-36(51)66)57-39(69)25(5)55-40(70)29(50)21-37(67)68/h11-14,23-26,29-35,38,64-65H,7-10,15-22,50H2,1-6H3,(H2,51,66)(H,55,70)(H,56,74)(H,57,69)(H,58,73)(H,59,75)(H,60,76)(H,61,71)(H,62,72)(H,67,68)(H,78,79)(H4,52,53,54)/t25-,26-,29-,30-,31-,32-,33-,34-,35-,38-/m0/s1 InChIKey: OVZGOCMQQXSJSD-UQIDJKEMSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
10