TPDB

3D PDB MODEL

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TPDB ID TPDB46962

Peptide_Name

ACE inhibitor (b-CN 193-198)

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

FermFooDB pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.

Sequence

YQQPVL

FASTA

>TPDB46962|ACE inhibitors;Antihypertensive|length=6
YQQPVL

Formula C35H54N8O10

Absent Amino Acids ARNDCEGHIKMFSTW

Common Amino Acids Q

Mass 746.86

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index 0.18

Hydrophobicity -0.317

Aliphatic Index 113.33

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 199.50

Polar Residues 3

number

0

A

0

R

0

N

0

D

0

C

0

E

2

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

6

Formula

C35H54N8O10

Mass

746.86

PI

5.94

Net Charge

-0

Boman Index

0.18

Hydrophobicity

-0.317

Chemical_Mass

746.8487

Monoisotopic_Mass

746.3950

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 280.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source FermFooDB

Authors Pihlanto-Leppala A., Rokka T., Korhonen H.

Title

Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal 8, 325-331(1998)

Year 1998

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C35H54N8O10/c1-18(2)16-25(35(52)53)41-33(50)29(19(3)4)42-32(49)26-6-5-15-43(26)34(51)24(12-14-28(38)46)40-31(48)23(11-13-27(37)45)39-30(47)22(36)17-20-7-9-21(44)10-8-20/h7-10,18-19,22-26,29,44H,5-6,11-17,36H2,1-4H3,(H2,37,45)(H2,38,46)(H,39,47)(H,40,48)(H,41,50)(H,42,49)(H,52,53)/t22-,23-,24-,25-,26-,29-/m0/s1 InChIKey=VDWSKVHLUNWXCP-WTWMNNMUSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 280.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB FermFooDB

Authors Pihlanto-Leppala A., Rokka T., Korhonen H.

Title

Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal 8, 325-331(1998)

Year 1998

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C35H54N8O10/c1-18(2)16-25(35(52)53)41-33(50)29(19(3)4)42-32(49)26-6-5-15-43(26)34(51)24(12-14-28(38)46)40-31(48)23(11-13-27(37)45)39-30(47)22(36)17-20-7-9-21(44)10-8-20/h7-10,18-19,22-26,29,44H,5-6,11-17,36H2,1-4H3,(H2,37,45)(H2,38,46)(H,39,47)(H,40,48)(H,41,50)(H,42,49)(H,52,53)/t22-,23-,24-,25-,26-,29-/m0/s1 InChIKey=VDWSKVHLUNWXCP-WTWMNNMUSA-N

Number_of_Residues

6