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Peptide record

TPDB46961

ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB46961
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
YPVQPFTE
Physicochemical Analysis
C47H65N9O14
ARNDCGHILKMSW
P
980.09
3.29
0
1
3
-1
1.64
-0.650
36.25
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
152.03
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
8
C47H65N9O14
980.09
3.29
-1
1.64
-0.650
980.0683
979.4635
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Lebrun I., Lebrun F. L. A. S., Henriques O. B., Carmona A. K., Juliano L., Camargo A. C.
Isolation and characterization of new bradykinin-potentiating octapeptide from b-casein. Can. J. Physiol. Pharmacol., 73, 85-91
1995
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C47H65N9O14/c1-25(2)38(53-42(64)35-12-7-21-55(35)45(67)30(48)23-28-13-15-29(58)16-14-28)43(65)50-31(17-19-36(49)59)46(68)56-22-8-11-34(56)41(63)52-33(24-27-9-5-4-6-10-27)40(62)54-39(26(3)57)44(66)51-32(47(69)70)18-20-37(60)61/h4-6,9-10,13-16,25-26,30-35,38-39,57-58H,7-8,11-12,17-24,48H2,1-3H3,(H2,49,59)(H,50,65)(H,51,66)(H,52,63)(H,53,64)(H,54,62)(H,60,61)(H,69,70)/t26-,30+,31+,32+,33+,34+,35+,38+,39+/m1/s1 InChIKey=AXAUQRQJKGBMFW-OAWHKPTDSA-N
Evidence 2 Activity

Activity

EC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Lebrun I., Lebrun F. L. A. S., Henriques O. B., Carmona A. K., Juliano L., Camargo A. C.
Isolation and characterization of new bradykinin-potentiating octapeptide from b-casein. Can. J. Physiol. Pharmacol., 73, 85-91
1995
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C47H65N9O14/c1-25(2)38(53-42(64)35-12-7-21-55(35)45(67)30(48)23-28-13-15-29(58)16-14-28)43(65)50-31(17-19-36(49)59)46(68)56-22-8-11-34(56)41(63)52-33(24-27-9-5-4-6-10-27)40(62)54-39(26(3)57)44(66)51-32(47(69)70)18-20-37(60)61/h4-6,9-10,13-16,25-26,30-35,38-39,57-58H,7-8,11-12,17-24,48H2,1-3H3,(H2,49,59)(H,50,65)(H,51,66)(H,52,63)(H,53,64)(H,54,62)(H,60,61)(H,69,70)/t26-,30+,31+,32+,33+,34+,35+,38+,39+/m1/s1 InChIKey=AXAUQRQJKGBMFW-OAWHKPTDSA-N
Additional Detail Fields 1 fields
8