TPDB

3D PDB MODEL

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TPDB ID TPDB46960

Peptide_Name

ACE inhibitor from as1-casein

Activity

ACE inhibitors Antihypertensive Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

YKVPQL

FASTA

>TPDB46960|ACE inhibitors;Antihypertensive;Neuropeptide|length=6
YKVPQL

Formula C36H58N8O9

Absent Amino Acids ARNDCEGHIMFSTW

Common Amino Acids QLKPYV

Mass 746.90

PI 9.74

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 0.59

Hydrophobicity -0.383

Aliphatic Index 113.33

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 199.49

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

1

L

1

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

6

Formula

C36H58N8O9

Mass

746.90

PI

9.74

Net Charge

+1

Boman Index

0.59

Hydrophobicity

-0.383

Chemical_Mass

746.8916

Monoisotopic_Mass

746.4313

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 22.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Maeno M., Yamamoto N., Takano T.

Title

Identification of antihypertensive peptides from casein hydrolysate produced by proteinase from Lactobacillus helveticus. J.Dairy Sci., 73, 1316-1321

Year 1996

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C36H58N8O9/c1-20(2)18-27(36(52)53)42-32(48)26(14-15-29(39)46)41-34(50)28-9-7-17-44(28)35(51)30(21(3)4)43-33(49)25(8-5-6-16-37)40-31(47)24(38)19-22-10-12-23(45)13-11-22/h10-13,20-21,24-28,30,45H,5-9,14-19,37-38H2,1-4H3,(H2,39,46)(H,40,47)(H,41,50)(H,42,48)(H,43,49)(H,52,53)/t24-,25-,26-,27-,28-,30-/m0/s1 InChIKey=JGZQEPWUJFWEFL-YUGXLDDKSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 22.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Maeno M., Yamamoto N., Takano T.

Title

Identification of antihypertensive peptides from casein hydrolysate produced by proteinase from Lactobacillus helveticus. J.Dairy Sci., 73, 1316-1321

Year 1996

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C36H58N8O9/c1-20(2)18-27(36(52)53)42-32(48)26(14-15-29(39)46)41-34(50)28-9-7-17-44(28)35(51)30(21(3)4)43-33(49)25(8-5-6-16-37)40-31(47)24(38)19-22-10-12-23(45)13-11-22/h10-13,20-21,24-28,30,45H,5-9,14-19,37-38H2,1-4H3,(H2,39,46)(H,40,47)(H,41,50)(H,42,48)(H,43,49)(H,52,53)/t24-,25-,26-,27-,28-,30-/m0/s1 InChIKey=JGZQEPWUJFWEFL-YUGXLDDKSA-N

Number_of_Residues

6