TPDB

3D PDB MODEL

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TPDB ID TPDB46959

Peptide_Name

ACE inhibitor (bCN fr.59-64)

Activity

ACE inhibitors Antihypertensive Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

VYPFPG

FASTA

>TPDB46959|ACE inhibitors;Antihypertensive;Neuropeptide|length=6
VYPFPG

Formula C35H46N6O8

Absent Amino Acids ARNDCEQHILKMSTW

Common Amino Acids P

Mass 678.79

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -1.09

Hydrophobicity 0.350

Aliphatic Index 48.33

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 219.51

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

1

F

2

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

6

Formula

C35H46N6O8

Mass

678.79

PI

5.94

Net Charge

-0

Boman Index

-1.09

Hydrophobicity

0.350

Chemical_Mass

678.7733

Monoisotopic_Mass

678.3366

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 221.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.

Title

Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J.Dairy Sci., 81(12) 3131-3138(1998)

Year 1998

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(O)=O InChI=1S/C35H46N6O8/c1-21(2)30(36)33(47)39-26(19-23-12-14-24(42)15-13-23)35(49)41-17-7-11-28(41)32(46)38-25(18-22-8-4-3-5-9-22)34(48)40-16-6-10-27(40)31(45)37-20-29(43)44/h3-5,8-9,12-15,21,25-28,30,42H,6-7,10-11,16-20,36H2,1-2H3,(H,37,45)(H,38,46)(H,39,47)(H,43,44)/t25-,26-,27-,28-,30-/m0/s1 InChIKey=XGHISKWRPVAFOO-KGEMVMTLSA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 221.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.

Title

Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J.Dairy Sci., 81(12) 3131-3138(1998)

Year 1998

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(O)=O InChI=1S/C35H46N6O8/c1-21(2)30(36)33(47)39-26(19-23-12-14-24(42)15-13-23)35(49)41-17-7-11-28(41)32(46)38-25(18-22-8-4-3-5-9-22)34(48)40-16-6-10-27(40)31(45)37-20-29(43)44/h3-5,8-9,12-15,21,25-28,30,42H,6-7,10-11,16-20,36H2,1-2H3,(H,37,45)(H,38,46)(H,39,47)(H,43,44)/t25-,26-,27-,28-,30-/m0/s1 InChIKey=XGHISKWRPVAFOO-KGEMVMTLSA-N

Number_of_Residues

6