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Peptide record

TPDB46957

human beta-casein fr. 55-61 ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB46957
human beta-casein fr. 55-61
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
TQSLVYP
Physicochemical Analysis
C37H58N8O12
ARNDCEGHIKMFW
QLPSTYV
806.91
5.94
0
0
3
-0
-0.13
0.014
97.14
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
184.65
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
7
C37H58N8O12
806.91
5.94
-0
-0.13
0.014
806.9005
806.4160
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
64.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C37H58N8O12/c1-18(2)15-24(41-33(52)26(17-46)43-31(50)23(12-13-28(38)49)40-34(53)29(39)20(5)47)32(51)44-30(19(3)4)35(54)42-25(16-21-8-10-22(48)11-9-21)36(55)45-14-6-7-27(45)37(56)57/h8-11,18-20,23-27,29-30,46-48H,6-7,12-17,39H2,1-5H3,(H2,38,49)(H,40,53)(H,41,52)(H,42,54)(H,43,50)(H,44,51)(H,56,57)/t20-,23+,24+,25+,26+,27+,29+,30+/m1/s1 InChIKey=KSLQQUTXTWMPFY-JJRNAQNQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
64.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C37H58N8O12/c1-18(2)15-24(41-33(52)26(17-46)43-31(50)23(12-13-28(38)49)40-34(53)29(39)20(5)47)32(51)44-30(19(3)4)35(54)42-25(16-21-8-10-22(48)11-9-21)36(55)45-14-6-7-27(45)37(56)57/h8-11,18-20,23-27,29-30,46-48H,6-7,12-17,39H2,1-5H3,(H2,38,49)(H,40,53)(H,41,52)(H,42,54)(H,43,50)(H,44,51)(H,56,57)/t20-,23+,24+,25+,26+,27+,29+,30+/m1/s1 InChIKey=KSLQQUTXTWMPFY-JJRNAQNQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
7