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Peptide record

TPDB46956

ACE inhibitor (bCN fr.80-90) ACE inhibitors Antihypertensive Neuropeptide iDPPIV standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB46956
ACE inhibitor (bCN fr.80-90)
ACE inhibitors Antihypertensive Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides
pep-lab Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 11-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Neuropeptide, and other sources) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
TPVVVPPFLQP
Physicochemical Analysis
C59H92N12O14
ARNDCEGHIKMSWY
P
1193.45
6.02
0
0
5
-0
1.04
0.782
114.55
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
4
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 4 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
11
C59H92N12O14
1193.45
6.02
-0
1.04
0.782
1193.4301
1192.6834
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
749.00 µM
ACE inhibitor
ah

Source & Reference

NA
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J.Dairy Sci., 81(12) 3131-3138(1998)
1998
Journal

Other

11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C59H92N12O14/c1-31(2)29-38(49(74)62-37(23-24-44(60)73)55(80)71-28-16-22-43(71)59(84)85)63-50(75)39(30-36-17-11-10-12-18-36)64-51(76)40-19-13-25-68(40)56(81)42-21-15-27-70(42)58(83)48(34(7)8)67-54(79)47(33(5)6)66-53(78)46(32(3)4)65-52(77)41-20-14-26-69(41)57(82)45(61)35(9)72/h10-12,17-18,31-35,37-43,45-48,72H,13-16,19-30,61H2,1-9H3,(H2,60,73)(H,62,74)(H,63,75)(H,64,76)(H,65,77)(H,66,78)(H,67,79)(H,84,85)/t35-,37+,38+,39+,40+,41+,42+,43+,45+,46+,47+,48+/m1/s1 InChIKey=MWKXTIXJHRNFHP-IYNVELHFSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
749.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J.Dairy Sci., 81(12) 3131-3138(1998)
1998
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C59H92N12O14/c1-31(2)29-38(49(74)62-37(23-24-44(60)73)55(80)71-28-16-22-43(71)59(84)85)63-50(75)39(30-36-17-11-10-12-18-36)64-51(76)40-19-13-25-68(40)56(81)42-21-15-27-70(42)58(83)48(34(7)8)67-54(79)47(33(5)6)66-53(78)46(32(3)4)65-52(77)41-20-14-26-69(41)57(82)45(61)35(9)72/h10-12,17-18,31-35,37-43,45-48,72H,13-16,19-30,61H2,1-9H3,(H2,60,73)(H,62,74)(H,63,75)(H,64,76)(H,65,77)(H,66,78)(H,67,79)(H,84,85)/t35-,37+,38+,39+,40+,41+,42+,43+,45+,46+,47+,48+/m1/s1 InChIKey=MWKXTIXJHRNFHP-IYNVELHFSA-N
Additional Detail Fields 1 fields
11