TPDB

3D PDB MODEL

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TPDB ID TPDB46955

Peptide_Name

ACE inhibitor from beta-casein

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

SKVLPVPE

FASTA

>TPDB46955|ACE inhibitors;Antihypertensive|length=8
SKVLPVPE

Formula C40H69N9O12

Absent Amino Acids ARNDCQGHIMFTWY

Common Amino Acids PV

Mass 868.04

PI 6.94

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -0

Boman Index 3.62

Hydrophobicity 0.100

Aliphatic Index 121.25

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

1

L

1

K

0

M

0

F

2

P

1

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 2

Length

8

Formula

C40H69N9O12

Mass

868.04

PI

6.94

Net Charge

-0

Boman Index

3.62

Hydrophobicity

0.100

Chemical_Mass

868.0262

Monoisotopic_Mass

867.5049

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Yamamoto N., Akino A., Takano T.

Title

Antihypertensive effects of peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 77, 917-922, 1994

Year 1994

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C40H69N9O12/c1-21(2)19-27(45-37(57)31(22(3)4)46-34(54)25(11-7-8-16-41)43-33(53)24(42)20-50)38(58)48-17-9-13-29(48)36(56)47-32(23(5)6)39(59)49-18-10-12-28(49)35(55)44-26(40(60)61)14-15-30(51)52/h21-29,31-32,50H,7-20,41-42H2,1-6H3,(H,43,53)(H,44,55)(H,45,57)(H,46,54)(H,47,56)(H,51,52)(H,60,61)/t24-,25-,26-,27-,28-,29-,31-,32-/m0/s1 InChIKey=PDGAFLCWTBAIEP-YBZKPHLHSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Yamamoto N., Akino A., Takano T.

Title

Antihypertensive effects of peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 77, 917-922, 1994

Year 1994

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C40H69N9O12/c1-21(2)19-27(45-37(57)31(22(3)4)46-34(54)25(11-7-8-16-41)43-33(53)24(42)20-50)38(58)48-17-9-13-29(48)36(56)47-32(23(5)6)39(59)49-18-10-12-28(49)35(55)44-26(40(60)61)14-15-30(51)52/h21-29,31-32,50H,7-20,41-42H2,1-6H3,(H,43,53)(H,44,55)(H,45,57)(H,46,54)(H,47,56)(H,51,52)(H,60,61)/t24-,25-,26-,27-,28-,29-,31-,32-/m0/s1 InChIKey=PDGAFLCWTBAIEP-YBZKPHLHSA-N

Number_of_Residues

8