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Peptide record

TPDB46953

human beta-casein fr. 54-61 ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB46953
human beta-casein fr. 54-61
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
QTQSLVYP
Physicochemical Analysis
C42H66N10O14
ARNDCEGHIKMFW
Q
935.04
5.94
0
0
3
-0
0.45
-0.425
85.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
1490
159.35
5
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
8
C42H66N10O14
935.04
5.94
-0
0.45
-0.425
935.0294
934.4744
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
73.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@@]([H])(N)CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C42H66N10O14/c1-20(2)17-27(37(60)50-33(21(3)4)39(62)48-28(18-23-8-10-24(55)11-9-23)41(64)52-16-6-7-30(52)42(65)66)47-38(61)29(19-53)49-36(59)26(13-15-32(45)57)46-40(63)34(22(5)54)51-35(58)25(43)12-14-31(44)56/h8-11,20-22,25-30,33-34,53-55H,6-7,12-19,43H2,1-5H3,(H2,44,56)(H2,45,57)(H,46,63)(H,47,61)(H,48,62)(H,49,59)(H,50,60)(H,51,58)(H,65,66)/t22-,25+,26+,27+,28+,29+,30+,33+,34+/m1/s1 InChIKey=LGVFXEXWCHOISE-NNUUHFFISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
73.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@@]([H])(N)CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C42H66N10O14/c1-20(2)17-27(37(60)50-33(21(3)4)39(62)48-28(18-23-8-10-24(55)11-9-23)41(64)52-16-6-7-30(52)42(65)66)47-38(61)29(19-53)49-36(59)26(13-15-32(45)57)46-40(63)34(22(5)54)51-35(58)25(43)12-14-31(44)56/h8-11,20-22,25-30,33-34,53-55H,6-7,12-19,43H2,1-5H3,(H2,44,56)(H2,45,57)(H,46,63)(H,47,61)(H,48,62)(H,49,59)(H,50,60)(H,51,58)(H,65,66)/t22-,25+,26+,27+,28+,29+,30+,33+,34+/m1/s1 InChIKey=LGVFXEXWCHOISE-NNUUHFFISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
8