TPDB

3D PDB MODEL

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TPDB ID TPDB46952

Peptide_Name

human beta-casein fr.56-61

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

QSLVYP

FASTA

>TPDB46952|ACE inhibitors;Antihypertensive|length=6
QSLVYP

Formula C33H51N7O10

Absent Amino Acids ARNDCEGHIKMFTW

Common Amino Acids QLPSYV

Mass 705.81

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -0.27

Hydrophobicity 0.133

Aliphatic Index 113.33

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 211.11

Polar Residues 3

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

1

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 1

Length

6

Formula

C33H51N7O10

Mass

705.81

PI

5.94

Net Charge

-0

Boman Index

-0.27

Hydrophobicity

0.133

Chemical_Mass

705.7969

Monoisotopic_Mass

705.3685

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 41.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114

Year 1989

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C33H51N7O10/c1-17(2)14-22(36-30(46)24(16-41)38-28(44)21(34)11-12-26(35)43)29(45)39-27(18(3)4)31(47)37-23(15-19-7-9-20(42)10-8-19)32(48)40-13-5-6-25(40)33(49)50/h7-10,17-18,21-25,27,41-42H,5-6,11-16,34H2,1-4H3,(H2,35,43)(H,36,46)(H,37,47)(H,38,44)(H,39,45)(H,49,50)/t21-,22-,23-,24-,25-,27-/m0/s1 InChIKey=AFJVLGCWHUAXEZ-UTHITJIJSA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 41.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C33H51N7O10/c1-17(2)14-22(36-30(46)24(16-41)38-28(44)21(34)11-12-26(35)43)29(45)39-27(18(3)4)31(47)37-23(15-19-7-9-20(42)10-8-19)32(48)40-13-5-6-25(40)33(49)50/h7-10,17-18,21-25,27,41-42H,5-6,11-16,34H2,1-4H3,(H2,35,43)(H,36,46)(H,37,47)(H,38,44)(H,39,45)(H,49,50)/t21-,22-,23-,24-,25-,27-/m0/s1 InChIKey=AFJVLGCWHUAXEZ-UTHITJIJSA-N

Number_of_Residues

6