TPDB

3D PDB MODEL

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TPDB ID TPDB46949

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

LDAQSAPLR

FASTA

>TPDB46949|ACE inhibitors;Antihypertensive|length=9
LDAQSAPLR

Formula C41H71N13O14

Absent Amino Acids NCEGHIKMFTWYV

Common Amino Acids AL

Mass 970.09

PI 6.78

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -0

Boman Index 1.74

Hydrophobicity -0.300

Aliphatic Index 108.89

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

2

A

1

R

0

N

1

D

0

C

0

E

1

Q

0

G

0

H

0

I

2

L

0

K

0

M

0

F

1

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

9

Formula

C41H71N13O14

Mass

970.09

PI

6.78

Net Charge

-0

Boman Index

1.74

Hydrophobicity

-0.300

Chemical_Mass

970.0783

Monoisotopic_Mass

969.5227

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 635.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Pihlanto-Leppala A. et al.

Title

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64

Year 2000

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C41H71N13O14/c1-19(2)15-23(42)33(60)51-27(17-31(57)58)35(62)47-21(5)32(59)49-24(11-12-30(43)56)34(61)53-28(18-55)37(64)48-22(6)39(66)54-14-8-10-29(54)38(65)52-26(16-20(3)4)36(63)50-25(40(67)68)9-7-13-46-41(44)45/h19-29,55H,7-18,42H2,1-6H3,(H2,43,56)(H,47,62)(H,48,64)(H,49,59)(H,50,63)(H,51,60)(H,52,65)(H,53,61)(H,57,58)(H,67,68)(H4,44,45,46)/t21-,22-,23-,24-,25-,26-,27-,28-,29-/m0/s1 InChIKey=RKWRGVFAKJIMRN-NVRHUXBUSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 635.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Pihlanto-Leppala A. et al.

Title

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64

Year 2000

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C41H71N13O14/c1-19(2)15-23(42)33(60)51-27(17-31(57)58)35(62)47-21(5)32(59)49-24(11-12-30(43)56)34(61)53-28(18-55)37(64)48-22(6)39(66)54-14-8-10-29(54)38(65)52-26(16-20(3)4)36(63)50-25(40(67)68)9-7-13-46-41(44)45/h19-29,55H,7-18,42H2,1-6H3,(H2,43,56)(H,47,62)(H,48,64)(H,49,59)(H,50,63)(H,51,60)(H,52,65)(H,53,61)(H,57,58)(H,67,68)(H4,44,45,46)/t21-,22-,23-,24-,25-,26-,27-,28-,29-/m0/s1 InChIKey=RKWRGVFAKJIMRN-NVRHUXBUSA-N

Number_of_Residues

9