TPDB

3D PDB MODEL

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TPDB ID TPDB46948

Peptide_Name

ACE inhibitor (alphas1-CN 142-147)

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

LAYFYP

FASTA

>TPDB46948|ACE inhibitors;Antihypertensive|length=6
LAYFYP

Formula C41H52N6O9

Absent Amino Acids RNDCEQGHIKMSTWV

Common Amino Acids Y

Mass 772.90

PI 5.88

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 5

Net Charge -0

Boman Index -3.29

Hydrophobicity 0.700

Aliphatic Index 81.67

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 385.56

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

6

Formula

C41H52N6O9

Mass

772.90

PI

5.88

Net Charge

-0

Boman Index

-3.29

Hydrophobicity

0.700

Chemical_Mass

772.8843

Monoisotopic_Mass

772.3783

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 65.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Pihlanto-Leppala A., Rokka T., Korhonen H.

Title

Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal, 8, 325-331 (1998)

Year 1998

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C41H52N6O9/c1-24(2)20-31(42)37(51)43-25(3)36(50)44-32(22-27-11-15-29(48)16-12-27)38(52)45-33(21-26-8-5-4-6-9-26)39(53)46-34(23-28-13-17-30(49)18-14-28)40(54)47-19-7-10-35(47)41(55)56/h4-6,8-9,11-18,24-25,31-35,48-49H,7,10,19-23,42H2,1-3H3,(H,43,51)(H,44,50)(H,45,52)(H,46,53)(H,55,56)/t25-,31-,32-,33-,34-,35-/m0/s1 InChIKey=UICVOYBOTPTQED-UCDZOKANSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 65.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Pihlanto-Leppala A., Rokka T., Korhonen H.

Title

Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal, 8, 325-331 (1998)

Year 1998

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C41H52N6O9/c1-24(2)20-31(42)37(51)43-25(3)36(50)44-32(22-27-11-15-29(48)16-12-27)38(52)45-33(21-26-8-5-4-6-9-26)39(53)46-34(23-28-13-17-30(49)18-14-28)40(54)47-19-7-10-35(47)41(55)56/h4-6,8-9,11-18,24-25,31-35,48-49H,7,10,19-23,42H2,1-3H3,(H,43,51)(H,44,50)(H,45,52)(H,46,53)(H,55,56)/t25-,31-,32-,33-,34-,35-/m0/s1 InChIKey=UICVOYBOTPTQED-UCDZOKANSA-N

Number_of_Residues

6