TPDB

3D PDB MODEL

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TPDB ID TPDB46947

Peptide_Name

ACE inhibitor (a-La 105-110)

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

LAHKAL

FASTA

>TPDB46947|ACE inhibitors;Antihypertensive|length=6
LAHKAL

Formula C30H53N9O7

Absent Amino Acids RNDCEQGIMFPSTWYV

Common Amino Acids AL

Mass 651.81

PI 10.10

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index 0.49

Hydrophobicity 0.683

Aliphatic Index 163.33

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

2

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

2

L

1

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 2 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

6

Formula

C30H53N9O7

Mass

651.81

PI

10.10

Net Charge

+1

Boman Index

0.49

Hydrophobicity

0.683

Chemical_Mass

651.7958

Monoisotopic_Mass

651.4056

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 621.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Pihlanto-Leppala A., Rokka T., Korhonen H.

Title

Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal 8, 325-331(1998)

Year 1998

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C30H53N9O7/c1-16(2)11-21(32)27(42)35-18(5)25(40)38-23(13-20-14-33-15-34-20)29(44)37-22(9-7-8-10-31)28(43)36-19(6)26(41)39-24(30(45)46)12-17(3)4/h14-19,21-24H,7-13,31-32H2,1-6H3,(H,33,34)(H,35,42)(H,36,43)(H,37,44)(H,38,40)(H,39,41)(H,45,46)/t18-,19-,21-,22-,23-,24-/m0/s1 InChIKey=NLCNCRBTXJLEIY-HEZDJTGRSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 621.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Pihlanto-Leppala A., Rokka T., Korhonen H.

Title

Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal 8, 325-331(1998)

Year 1998

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C30H53N9O7/c1-16(2)11-21(32)27(42)35-18(5)25(40)38-23(13-20-14-33-15-34-20)29(44)37-22(9-7-8-10-31)28(43)36-19(6)26(41)39-24(30(45)46)12-17(3)4/h14-19,21-24H,7-13,31-32H2,1-6H3,(H,33,34)(H,35,42)(H,36,43)(H,37,44)(H,38,40)(H,39,41)(H,45,46)/t18-,19-,21-,22-,23-,24-/m0/s1 InChIKey=NLCNCRBTXJLEIY-HEZDJTGRSA-N

Number_of_Residues

6