Back to search

Peptide record

TPDB46945

human beta-casein fr. 48-61 ACE inhibitors Antihypertensive standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB46945
human beta-casein fr. 48-61
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 14-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
KIHPFAQTQSLVYP
Physicochemical Analysis
C77H117N19O20
RNDCEGMW
QP
1628.89
9.74
2
0
6
+1
1.24
-0.214
83.57
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
91.47
5
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
1
H
1
I
1
L
1
K
0
M
1
F
2
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 1 L: 1 K: 1 M: 0 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
14
C77H117N19O20
1628.89
9.74
+1
1.24
-0.214
1628.8635
1627.8695
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
39.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102
1990
Journal

Other

14
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C77H117N19O20/c1-9-42(6)62(93-65(103)49(79)19-13-14-30-78)73(111)90-55(36-47-37-82-39-83-47)76(114)95-31-15-20-57(95)71(109)88-53(34-45-17-11-10-12-18-45)68(106)84-43(7)64(102)85-51(27-29-60(81)101)67(105)94-63(44(8)98)74(112)86-50(26-28-59(80)100)66(104)91-56(38-97)70(108)87-52(33-40(2)3)69(107)92-61(41(4)5)72(110)89-54(35-46-22-24-48(99)25-23-46)75(113)96-32-16-21-58(96)77(115)116/h10-12,17-18,22-25,37,39-44,49-58,61-63,97-99H,9,13-16,19-21,26-36,38,78-79H2,1-8H3,(H2,80,100)(H2,81,101)(H,82,83)(H,84,106)(H,85,102)(H,86,112)(H,87,108)(H,88,109)(H,89,110)(H,90,111)(H,91,104)(H,92,107)(H,93,103)(H,94,105)(H,115,116)/t42-,43-,44+,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,61-,62-,63-/m0/s1 InChIKey=MFLLOZPTIRCPBB-HGUIBHADSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
39.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
14
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C77H117N19O20/c1-9-42(6)62(93-65(103)49(79)19-13-14-30-78)73(111)90-55(36-47-37-82-39-83-47)76(114)95-31-15-20-57(95)71(109)88-53(34-45-17-11-10-12-18-45)68(106)84-43(7)64(102)85-51(27-29-60(81)101)67(105)94-63(44(8)98)74(112)86-50(26-28-59(80)100)66(104)91-56(38-97)70(108)87-52(33-40(2)3)69(107)92-61(41(4)5)72(110)89-54(35-46-22-24-48(99)25-23-46)75(113)96-32-16-21-58(96)77(115)116/h10-12,17-18,22-25,37,39-44,49-58,61-63,97-99H,9,13-16,19-21,26-36,38,78-79H2,1-8H3,(H2,80,100)(H2,81,101)(H,82,83)(H,84,106)(H,85,102)(H,86,112)(H,87,108)(H,88,109)(H,89,110)(H,90,111)(H,91,104)(H,92,107)(H,93,103)(H,94,105)(H,115,116)/t42-,43-,44+,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,61-,62-,63-/m0/s1 InChIKey=MFLLOZPTIRCPBB-HGUIBHADSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
14