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Peptide record

TPDB46944

human beta-casein fr. 49-61 ACE inhibitors Antihypertensive standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB46944
human beta-casein fr. 49-61
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 13-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IHPFAQTQSLVYP
Physicochemical Analysis
C71H105N17O19
RNDCEGKMW
QP
1500.72
7.77
1
0
6
+0
0.25
0.069
90.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1490
99.29
5
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
1
H
1
I
1
L
0
K
0
M
1
F
2
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 1 L: 1 K: 0 M: 0 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
13
C71H105N17O19
1500.72
7.77
+0
0.25
0.069
1500.6917
1499.7748
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
19.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

13
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC1=CN=CN1)NC(=O)[C@@]([H])(N)[C@@H](C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C71H105N17O19/c1-9-38(6)56(74)66(101)82-50(32-43-33-75-35-76-43)70(105)87-27-13-17-52(87)65(100)81-48(30-41-15-11-10-12-16-41)62(97)77-39(7)59(94)78-46(24-26-55(73)93)61(96)86-58(40(8)90)68(103)79-45(23-25-54(72)92)60(95)84-51(34-89)64(99)80-47(29-36(2)3)63(98)85-57(37(4)5)67(102)83-49(31-42-19-21-44(91)22-20-42)69(104)88-28-14-18-53(88)71(106)107/h10-12,15-16,19-22,33,35-40,45-53,56-58,89-91H,9,13-14,17-18,23-32,34,74H2,1-8H3,(H2,72,92)(H2,73,93)(H,75,76)(H,77,97)(H,78,94)(H,79,103)(H,80,99)(H,81,100)(H,82,101)(H,83,102)(H,84,95)(H,85,98)(H,86,96)(H,106,107)/t38-,39-,40+,45-,46-,47-,48-,49-,50-,51-,52-,53-,56-,57-,58-/m0/s1 InChIKey=YEFVSFQZEOVLJB-MIZIYVFQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
19.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
13
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC1=CN=CN1)NC(=O)[C@@]([H])(N)[C@@H](C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C71H105N17O19/c1-9-38(6)56(74)66(101)82-50(32-43-33-75-35-76-43)70(105)87-27-13-17-52(87)65(100)81-48(30-41-15-11-10-12-16-41)62(97)77-39(7)59(94)78-46(24-26-55(73)93)61(96)86-58(40(8)90)68(103)79-45(23-25-54(72)92)60(95)84-51(34-89)64(99)80-47(29-36(2)3)63(98)85-57(37(4)5)67(102)83-49(31-42-19-21-44(91)22-20-42)69(104)88-28-14-18-53(88)71(106)107/h10-12,15-16,19-22,33,35-40,45-53,56-58,89-91H,9,13-14,17-18,23-32,34,74H2,1-8H3,(H2,72,92)(H2,73,93)(H,75,76)(H,77,97)(H,78,94)(H,79,103)(H,80,99)(H,81,100)(H,82,101)(H,83,102)(H,84,95)(H,85,98)(H,86,96)(H,106,107)/t38-,39-,40+,45-,46-,47-,48-,49-,50-,51-,52-,53-,56-,57-,58-/m0/s1 InChIKey=YEFVSFQZEOVLJB-MIZIYVFQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
13