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Peptide record

TPDB46942

human beta-casein fr. 52-61 ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB46942
human beta-casein fr. 52-61
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
FAQTQSLVYP
Physicochemical Analysis
C54H80N12O16
RNDCEGHIKMW
Q
1153.30
5.94
0
0
5
-0
-0.85
0.120
78.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
129.19
5
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
10
C54H80N12O16
1153.30
5.94
-0
-0.85
0.120
1153.2806
1152.5796
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
25.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C54H80N12O16/c1-27(2)23-37(49(76)64-43(28(3)4)51(78)62-38(25-32-14-16-33(69)17-15-32)53(80)66-22-10-13-40(66)54(81)82)61-50(77)39(26-67)63-47(74)35(18-20-41(56)70)60-52(79)44(30(6)68)65-48(75)36(19-21-42(57)71)59-45(72)29(5)58-46(73)34(55)24-31-11-8-7-9-12-31/h7-9,11-12,14-17,27-30,34-40,43-44,67-69H,10,13,18-26,55H2,1-6H3,(H2,56,70)(H2,57,71)(H,58,73)(H,59,72)(H,60,79)(H,61,77)(H,62,78)(H,63,74)(H,64,76)(H,65,75)(H,81,82)/t29-,30+,34-,35-,36-,37-,38-,39-,40-,43-,44-/m0/s1 InChIKey=OBEGCAFSVONNIK-GGJQRRLPSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
25.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C54H80N12O16/c1-27(2)23-37(49(76)64-43(28(3)4)51(78)62-38(25-32-14-16-33(69)17-15-32)53(80)66-22-10-13-40(66)54(81)82)61-50(77)39(26-67)63-47(74)35(18-20-41(56)70)60-52(79)44(30(6)68)65-48(75)36(19-21-42(57)71)59-45(72)29(5)58-46(73)34(55)24-31-11-8-7-9-12-31/h7-9,11-12,14-17,27-30,34-40,43-44,67-69H,10,13,18-26,55H2,1-6H3,(H2,56,70)(H2,57,71)(H,58,73)(H,59,72)(H,60,79)(H,61,77)(H,62,78)(H,63,74)(H,64,76)(H,65,75)(H,81,82)/t29-,30+,34-,35-,36-,37-,38-,39-,40-,43-,44-/m0/s1 InChIKey=OBEGCAFSVONNIK-GGJQRRLPSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
10