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Peptide record

TPDB46941

ACE inhibitor (alphas1-CN 157-164) ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB46941
ACE inhibitor (alphas1-CN 157-164)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
DAYPSGAW
Physicochemical Analysis
C40H51N9O13
RNCEQHILKMFTV
A
865.90
3.10
0
1
4
-1
-1.31
-0.613
25.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
6990
807.25
2
Residue Composition
number
2
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
8
C40H51N9O13
865.90
3.10
-1
-1.31
-0.613
865.8834
865.3594
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
98.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Pihlanto-Leppala A., Rokka T., Korhonen H.
Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal, 8, 325-331 (1998)
1998
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CC=C(O)C=C1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O InChI=1S/C40H51N9O13/c1-20(34(55)47-29(40(61)62)15-23-17-42-27-7-4-3-6-25(23)27)44-32(52)18-43-37(58)30(19-50)48-38(59)31-8-5-13-49(31)39(60)28(14-22-9-11-24(51)12-10-22)46-35(56)21(2)45-36(57)26(41)16-33(53)54/h3-4,6-7,9-12,17,20-21,26,28-31,42,50-51H,5,8,13-16,18-19,41H2,1-2H3,(H,43,58)(H,44,52)(H,45,57)(H,46,56)(H,47,55)(H,48,59)(H,53,54)(H,61,62)/t20-,21-,26-,28-,29-,30-,31-/m0/s1 InChIKey=KLRLCROZWUROLB-JCMIXXOKSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
98.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Pihlanto-Leppala A., Rokka T., Korhonen H.
Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal, 8, 325-331 (1998)
1998
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CC=C(O)C=C1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O InChI=1S/C40H51N9O13/c1-20(34(55)47-29(40(61)62)15-23-17-42-27-7-4-3-6-25(23)27)44-32(52)18-43-37(58)30(19-50)48-38(59)31-8-5-13-49(31)39(60)28(14-22-9-11-24(51)12-10-22)46-35(56)21(2)45-36(57)26(41)16-33(53)54/h3-4,6-7,9-12,17,20-21,26,28-31,42,50-51H,5,8,13-16,18-19,41H2,1-2H3,(H,43,58)(H,44,52)(H,45,57)(H,46,56)(H,47,55)(H,48,59)(H,53,54)(H,61,62)/t20-,21-,26-,28-,29-,30-,31-/m0/s1 InChIKey=KLRLCROZWUROLB-JCMIXXOKSA-N
Additional Detail Fields 1 fields
8