TPDB

3D PDB MODEL

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TPDB ID TPDB46940

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

CMENSA

FASTA

>TPDB46940|ACE inhibitors;Antihypertensive|length=6
CMENSA

Formula C23H39N7O11S2

Absent Amino Acids RDQGHILKFPTWYV

Common Amino Acids ANCEMS

Mass 653.72

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -1

Boman Index 1.93

Hydrophobicity -0.267

Aliphatic Index 16.67

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

1

A

0

R

1

N

0

D

1

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

1

M

0

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 1 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

6

Formula

C23H39N7O11S2

Mass

653.72

PI

3.29

Net Charge

-1

Boman Index

1.93

Hydrophobicity

-0.267

Chemical_Mass

653.7267

Monoisotopic_Mass

653.2140

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 788.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Pihlanto-Leppala A. et al.

Title

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64

Year 2000

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CS)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C23H39N7O11S2/c1-10(23(40)41)26-22(39)15(8-31)30-21(38)14(7-16(25)32)29-19(36)12(3-4-17(33)34)28-20(37)13(5-6-43-2)27-18(35)11(24)9-42/h10-15,31,42H,3-9,24H2,1-2H3,(H2,25,32)(H,26,39)(H,27,35)(H,28,37)(H,29,36)(H,30,38)(H,33,34)(H,40,41)/t10-,11-,12-,13-,14-,15-/m0/s1 InChIKey=SBIFIUSJSNDFBH-LZXPERKUSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 788.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Pihlanto-Leppala A. et al.

Title

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64

Year 2000

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CS)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C23H39N7O11S2/c1-10(23(40)41)26-22(39)15(8-31)30-21(38)14(7-16(25)32)29-19(36)12(3-4-17(33)34)28-20(37)13(5-6-43-2)27-18(35)11(24)9-42/h10-15,31,42H,3-9,24H2,1-2H3,(H2,25,32)(H,26,39)(H,27,35)(H,28,37)(H,29,36)(H,30,38)(H,33,34)(H,40,41)/t10-,11-,12-,13-,14-,15-/m0/s1 InChIKey=SBIFIUSJSNDFBH-LZXPERKUSA-N

Number_of_Residues

6