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Peptide record

TPDB46939

human beta-casein fr.53-61 ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB46939
human beta-casein fr.53-61
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
AQTQSLVYP
Physicochemical Analysis
C45H71N11O15
RNDCEGHIKMFW
Q
1006.12
5.94
0
0
4
-0
0.28
-0.178
86.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
148.09
5
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
9
C45H71N11O15
1006.12
5.94
-0
0.28
-0.178
1006.1071
1005.5114
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
76.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C45H71N11O15/c1-21(2)18-29(40(65)54-35(22(3)4)42(67)52-30(19-25-9-11-26(59)12-10-25)44(69)56-17-7-8-32(56)45(70)71)51-41(66)31(20-57)53-38(63)27(13-15-33(47)60)50-43(68)36(24(6)58)55-39(64)28(14-16-34(48)61)49-37(62)23(5)46/h9-12,21-24,27-32,35-36,57-59H,7-8,13-20,46H2,1-6H3,(H2,47,60)(H2,48,61)(H,49,62)(H,50,68)(H,51,66)(H,52,67)(H,53,63)(H,54,65)(H,55,64)(H,70,71)/t23-,24+,27-,28-,29-,30-,31-,32-,35-,36-/m0/s1 InChIKey=OWXZTWVXOYIUHA-SAMXSJHTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
76.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C45H71N11O15/c1-21(2)18-29(40(65)54-35(22(3)4)42(67)52-30(19-25-9-11-26(59)12-10-25)44(69)56-17-7-8-32(56)45(70)71)51-41(66)31(20-57)53-38(63)27(13-15-33(47)60)50-43(68)36(24(6)58)55-39(64)28(14-16-34(48)61)49-37(62)23(5)46/h9-12,21-24,27-32,35-36,57-59H,7-8,13-20,46H2,1-6H3,(H2,47,60)(H2,48,61)(H,49,62)(H,50,68)(H,51,66)(H,52,67)(H,53,63)(H,54,65)(H,55,64)(H,70,71)/t23-,24+,27-,28-,29-,30-,31-,32-,35-,36-/m0/s1 InChIKey=OWXZTWVXOYIUHA-SAMXSJHTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
9