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Peptide record

TPDB46937

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB46937
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
TFPHGP
Physicochemical Analysis
C31H42N8O8
ARNDCEQILKMSWYV
P
654.72
7.85
1
0
1
+0
0.88
-0.783
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C31H42N8O8
654.72
7.85
+0
0.88
-0.783
654.7123
654.3116
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
833.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Liu R., Zhu Y., Chen J., Wu H., Shi L., Wang X., Wang L.
Purification and identification of antihypertensive peptides from seaweed pipefish (Syngnathus schlegeli) muscle protein hydrolysate. Food Res. Int., 44, 703-707, 2011
2011
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)Cc1[nH]cnc1)Cc1ccccc1)[C@@H](C)O InChI=1S/C31H42N8O8/c1-18(40)26(32)29(44)37-22(13-19-7-3-2-4-8-19)30(45)39-12-5-9-23(39)28(43)36-21(14-20-15-33-17-35-20)27(42)34-16-25(41)38-11-6-10-24(38)31(46)47/h2-4,7-8,15,17-18,21-24,26,40H,5-6,9-14,16,32H2,1H3,(H,33,35)(H,34,42)(H,36,43)(H,37,44)(H,46,47)/t18-,21+,22+,23+,24+,26+/m1/s1 InChIKey: VQSXVZFPJNVNNR-VXCGBPEZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
833.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Liu R., Zhu Y., Chen J., Wu H., Shi L., Wang X., Wang L.
Purification and identification of antihypertensive peptides from seaweed pipefish (Syngnathus schlegeli) muscle protein hydrolysate. Food Res. Int., 44, 703-707, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)Cc1[nH]cnc1)Cc1ccccc1)[C@@H](C)O InChI=1S/C31H42N8O8/c1-18(40)26(32)29(44)37-22(13-19-7-3-2-4-8-19)30(45)39-12-5-9-23(39)28(43)36-21(14-20-15-33-17-35-20)27(42)34-16-25(41)38-11-6-10-24(38)31(46)47/h2-4,7-8,15,17-18,21-24,26,40H,5-6,9-14,16,32H2,1H3,(H,33,35)(H,34,42)(H,36,43)(H,37,44)(H,46,47)/t18-,21+,22+,23+,24+,26+/m1/s1 InChIKey: VQSXVZFPJNVNNR-VXCGBPEZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6