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Peptide record

TPDB46933

ACE inhibitor ACE inhibitors Antihypertensive standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB46933
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 13-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
WPEAAELMMEVDP
Physicochemical Analysis
C67H100N14O22S2
RNCQGHIKFSTY
E
1517.73
2.89
0
4
7
-4
5.05
-0.208
67.69
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
362.38
0
Residue Composition
number
2
A
0
R
0
N
1
D
0
C
3
E
0
Q
0
G
0
H
0
I
1
L
0
K
2
M
0
F
2
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 0 E: 3 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 2 F: 0 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
13
C67H100N14O22S2
1517.73
2.89
-4
5.05
-0.208
1517.7197
1516.6554
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
21.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Qian Z. J., Je J. Y., Kim S. K.
Antihypertensive effect of angiotensin I converting enzyme-inhibitory peptide from hydrolysates of bigeye tuna dark muscle, Thunnus obesus. J. Agric. Food Chem., 55, 8398–8403, 2007
2007
Journal

Other

13
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)O)CCC2)CC(=O)O)C(C)C)CCC(=O)O)CCSC)CCSC)CC(C)C)CCC(=O)O)C)C)CCC(=O)O)CCC1)Cc1c[nH]c2c1cccc2 InChI=1S/C67H100N14O22S2/c1-33(2)29-46(62(97)75-45(24-28-105-8)60(95)74-44(23-27-104-7)59(94)73-43(19-22-52(86)87)61(96)79-54(34(3)4)64(99)78-47(31-53(88)89)66(101)81-26-12-16-49(81)67(102)103)77-58(93)42(18-21-51(84)85)72-56(91)36(6)70-55(90)35(5)71-57(92)41(17-20-50(82)83)76-63(98)48-15-11-25-80(48)65(100)39(68)30-37-32-69-40-14-10-9-13-38(37)40/h9-10,13-14,32-36,39,41-49,54,69H,11-12,15-31,68H2,1-8H3,(H,70,90)(H,71,92)(H,72,91)(H,73,94)(H,74,95)(H,75,97)(H,76,98)(H,77,93)(H,78,99)(H,79,96)(H,82,83)(H,84,85)(H,86,87)(H,88,89)(H,102,103)/t35-,36-,39-,41-,42-,43-,44-,45-,46-,47-,48-,49-,54-/m0/s1 InChIKey: OCCWLBFRXWCFSF-NVCQNZFESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
21.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Qian Z. J., Je J. Y., Kim S. K.
Antihypertensive effect of angiotensin I converting enzyme-inhibitory peptide from hydrolysates of bigeye tuna dark muscle, Thunnus obesus. J. Agric. Food Chem., 55, 8398–8403, 2007
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
13
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)O)CCC2)CC(=O)O)C(C)C)CCC(=O)O)CCSC)CCSC)CC(C)C)CCC(=O)O)C)C)CCC(=O)O)CCC1)Cc1c[nH]c2c1cccc2 InChI=1S/C67H100N14O22S2/c1-33(2)29-46(62(97)75-45(24-28-105-8)60(95)74-44(23-27-104-7)59(94)73-43(19-22-52(86)87)61(96)79-54(34(3)4)64(99)78-47(31-53(88)89)66(101)81-26-12-16-49(81)67(102)103)77-58(93)42(18-21-51(84)85)72-56(91)36(6)70-55(90)35(5)71-57(92)41(17-20-50(82)83)76-63(98)48-15-11-25-80(48)65(100)39(68)30-37-32-69-40-14-10-9-13-38(37)40/h9-10,13-14,32-36,39,41-49,54,69H,11-12,15-31,68H2,1-8H3,(H,70,90)(H,71,92)(H,72,91)(H,73,94)(H,74,95)(H,75,97)(H,76,98)(H,77,93)(H,78,99)(H,79,96)(H,82,83)(H,84,85)(H,86,87)(H,88,89)(H,102,103)/t35-,36-,39-,41-,42-,43-,44-,45-,46-,47-,48-,49-,54-/m0/s1 InChIKey: OCCWLBFRXWCFSF-NVCQNZFESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
13