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Peptide record

TPDB46931

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB46931
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PTHIKWGD
Physicochemical Analysis
C44H64N12O12
ARNCEQLMFSYV
DGHIKPTW
953.07
7.81
2
1
2
+0
1.62
-1.213
48.75
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
577.09
1
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
1
H
1
I
0
L
1
K
0
M
0
F
1
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
8
C44H64N12O12
953.07
7.81
+0
1.62
-1.213
953.0496
952.4752
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.50 µM
ACE inhibitor
ah

Source & Reference

NA
Kohama Y., Matsumoto S., Oka H., Teramoto T., Okabe M., Mimura T.
Isolation of angiotensin-converting enzyme inhibitor from tuna muscle. Biochem. Biophys. Res. Commun., 155, 332-337
1988
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@]([H])(CC(O)=O)C(O)=O)[C@@]([H])(C)CC InChI=1S/C44H64N12O12/c1-4-23(2)36(55-41(64)32(17-26-20-46-22-50-26)54-43(66)37(24(3)57)56-39(62)29-13-9-15-47-29)42(65)52-30(12-7-8-14-45)40(63)53-31(16-25-19-48-28-11-6-5-10-27(25)28)38(61)49-21-34(58)51-33(44(67)68)18-35(59)60/h5-6,10-11,19-20,22-24,29-33,36-37,47-48,57H,4,7-9,12-18,21,45H2,1-3H3,(H,46,50)(H,49,61)(H,51,58)(H,52,65)(H,53,63)(H,54,66)(H,55,64)(H,56,62)(H,59,60)(H,67,68)/t23-,24+,29-,30-,31-,32-,33-,36-,37-/m0/s1 InChIKey=QEULPEXEDWQVEI-DAZSAYDVSA-N EC50 value from article: Murray B. A., FitzGerald R. J., 2007. Curr. Pharm. Des. 13, 8, 773-791.
Evidence 2 Activity

Activity

IC50
Antihypertensive
1.50 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohama Y., Matsumoto S., Oka H., Teramoto T., Okabe M., Mimura T.
Isolation of angiotensin-converting enzyme inhibitor from tuna muscle. Biochem. Biophys. Res. Commun., 155, 332-337
1988
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@]([H])(CC(O)=O)C(O)=O)[C@@]([H])(C)CC InChI=1S/C44H64N12O12/c1-4-23(2)36(55-41(64)32(17-26-20-46-22-50-26)54-43(66)37(24(3)57)56-39(62)29-13-9-15-47-29)42(65)52-30(12-7-8-14-45)40(63)53-31(16-25-19-48-28-11-6-5-10-27(25)28)38(61)49-21-34(58)51-33(44(67)68)18-35(59)60/h5-6,10-11,19-20,22-24,29-33,36-37,47-48,57H,4,7-9,12-18,21,45H2,1-3H3,(H,46,50)(H,49,61)(H,51,58)(H,52,65)(H,53,63)(H,54,66)(H,55,64)(H,56,62)(H,59,60)(H,67,68)/t23-,24+,29-,30-,31-,32-,33-,36-,37-/m0/s1 InChIKey=QEULPEXEDWQVEI-DAZSAYDVSA-N EC50 value from article: Murray B. A., FitzGerald R. J., 2007. Curr. Pharm. Des. 13, 8, 773-791.
Additional Detail Fields 1 fields
8