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Peptide record

TPDB46930

ACE inhibitor ACE inhibitors Antihypertensive standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB46930
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 12-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
HERDPTHIKWGD
Physicochemical Analysis
C65H95N21O20
ANCQLMFSYV
DH
1490.60
6.03
4
3
2
-1
6.64
-2.033
32.50
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5500
368.98
1
Residue Composition
number
0
A
1
R
0
N
2
D
0
C
1
E
0
Q
1
G
2
H
1
I
0
L
1
K
0
M
0
F
1
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 0 E: 1 Q: 0 G: 1 H: 2 I: 1 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C65H95N21O20
1490.60
6.03
-1
6.64
-2.033
1490.5747
1489.7041
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
8.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Hasan F., Kitagawa M., Kumada Y., Hashimoto N., Shiiba M., Katoh S., Terashima M.
Production kinetics of angiotensin-I converting enzyme inhibitory peptides from bonito meat in artificial gastric juice. Process Biochem., 41, 505-511, 2006
2006
Journal

Other

12
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)CC(=O)O)Cc1c2ccccc2[nH]c1)CCCCN)[C@@H](C)CC)Cc1[nH]cnc1)[C@@H](C)O)CC(=O)O)CCCNC(=N)N)CCC(=O)O)Cc1[nH]cnc1 InChI=1S/C65H95N21O20/c1-4-32(2)52(61(102)80-40(13-7-8-18-66)56(97)81-43(21-34-26-73-39-12-6-5-11-37(34)39)55(96)74-29-48(88)77-46(64(105)106)25-51(93)94)84-59(100)44(23-36-28-71-31-76-36)82-62(103)53(33(3)87)85-60(101)47-15-10-20-86(47)63(104)45(24-50(91)92)83-57(98)41(14-9-19-72-65(68)69)79-58(99)42(16-17-49(89)90)78-54(95)38(67)22-35-27-70-30-75-35/h5-6,11-12,26-28,30-33,38,40-47,52-53,73,87H,4,7-10,13-25,29,66-67H2,1-3H3,(H,70,75)(H,71,76)(H,74,96)(H,77,88)(H,78,95)(H,79,99)(H,80,102)(H,81,97)(H,82,103)(H,83,98)(H,84,100)(H,85,101)(H,89,90)(H,91,92)(H,93,94)(H,105,106)(H4,68,69,72)/t32-,33+,38-,40-,41-,42-,43-,44-,45-,46-,47-,52-,53-/m0/s1 InChIKey: GTEYDIOJLDTETK-BXJXJFHOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
8.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Hasan F., Kitagawa M., Kumada Y., Hashimoto N., Shiiba M., Katoh S., Terashima M.
Production kinetics of angiotensin-I converting enzyme inhibitory peptides from bonito meat in artificial gastric juice. Process Biochem., 41, 505-511, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
12
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)CC(=O)O)Cc1c2ccccc2[nH]c1)CCCCN)[C@@H](C)CC)Cc1[nH]cnc1)[C@@H](C)O)CC(=O)O)CCCNC(=N)N)CCC(=O)O)Cc1[nH]cnc1 InChI=1S/C65H95N21O20/c1-4-32(2)52(61(102)80-40(13-7-8-18-66)56(97)81-43(21-34-26-73-39-12-6-5-11-37(34)39)55(96)74-29-48(88)77-46(64(105)106)25-51(93)94)84-59(100)44(23-36-28-71-31-76-36)82-62(103)53(33(3)87)85-60(101)47-15-10-20-86(47)63(104)45(24-50(91)92)83-57(98)41(14-9-19-72-65(68)69)79-58(99)42(16-17-49(89)90)78-54(95)38(67)22-35-27-70-30-75-35/h5-6,11-12,26-28,30-33,38,40-47,52-53,73,87H,4,7-10,13-25,29,66-67H2,1-3H3,(H,70,75)(H,71,76)(H,74,96)(H,77,88)(H,78,95)(H,79,99)(H,80,102)(H,81,97)(H,82,103)(H,83,98)(H,84,100)(H,85,101)(H,89,90)(H,91,92)(H,93,94)(H,105,106)(H4,68,69,72)/t32-,33+,38-,40-,41-,42-,43-,44-,45-,46-,47-,52-,53-/m0/s1 InChIKey: GTEYDIOJLDTETK-BXJXJFHOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
12