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Peptide record

TPDB46929

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB46929
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
DYGLYP
Physicochemical Analysis
C35H46N6O11
ARNCEQHIKMFSTWV
Y
726.78
3.10
0
1
3
-1
-0.75
-0.717
65.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
2980
410.03
2
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
6
C35H46N6O11
726.78
3.10
-1
-0.75
-0.717
726.7715
726.3213
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
62.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Yokoyama K., Chiba H., and Yoshikawa M.
Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545
1992
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C35H46N6O11/c1-19(2)14-25(33(49)40-27(16-21-7-11-23(43)12-8-21)34(50)41-13-3-4-28(41)35(51)52)38-29(44)18-37-32(48)26(15-20-5-9-22(42)10-6-20)39-31(47)24(36)17-30(45)46/h5-12,19,24-28,42-43H,3-4,13-18,36H2,1-2H3,(H,37,48)(H,38,44)(H,39,47)(H,40,49)(H,45,46)(H,51,52)/t24-,25-,26-,27-,28-/m0/s1 InChIKey=LKRJGCZOYWJFTD-XLIKFSOKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
62.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Yokoyama K., Chiba H., and Yoshikawa M.
Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545
1992
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C35H46N6O11/c1-19(2)14-25(33(49)40-27(16-21-7-11-23(43)12-8-21)34(50)41-13-3-4-28(41)35(51)52)38-29(44)18-37-32(48)26(15-20-5-9-22(42)10-6-20)39-31(47)24(36)17-30(45)46/h5-12,19,24-28,42-43H,3-4,13-18,36H2,1-2H3,(H,37,48)(H,38,44)(H,39,47)(H,40,49)(H,45,46)(H,51,52)/t24-,25-,26-,27-,28-/m0/s1 InChIKey=LKRJGCZOYWJFTD-XLIKFSOKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
6