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Peptide record

TPDB46927

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB46927
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IKPLNY
Physicochemical Analysis
C36H58N8O9
ARDCEQGHMFSTWV
NILKPY
746.90
9.74
1
0
3
+1
0.05
-0.333
130.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1490
199.49
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
6
C36H58N8O9
746.90
9.74
+1
0.05
-0.333
746.8916
746.4313
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
43.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Yokoyama K., Chiba H., and Yoshikawa M.
Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545
1992
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C36H58N8O9/c1-5-21(4)30(39)34(50)40-24(9-6-7-15-37)35(51)44-16-8-10-28(44)33(49)42-25(17-20(2)3)31(47)41-26(19-29(38)46)32(48)43-27(36(52)53)18-22-11-13-23(45)14-12-22/h11-14,20-21,24-28,30,45H,5-10,15-19,37,39H2,1-4H3,(H2,38,46)(H,40,50)(H,41,47)(H,42,49)(H,43,48)(H,52,53)/t21-,24-,25-,26-,27-,28-,30-/m0/s1 InChIKey=UZGGSGVPDQTMCA-YYNHRMGXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
43.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Yokoyama K., Chiba H., and Yoshikawa M.
Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545
1992
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C36H58N8O9/c1-5-21(4)30(39)34(50)40-24(9-6-7-15-37)35(51)44-16-8-10-28(44)33(49)42-25(17-20(2)3)31(47)41-26(19-29(38)46)32(48)43-27(36(52)53)18-22-11-13-23(45)14-12-22/h11-14,20-21,24-28,30,45H,5-10,15-19,37,39H2,1-4H3,(H2,38,46)(H,40,50)(H,41,47)(H,42,49)(H,43,48)(H,52,53)/t21-,24-,25-,26-,27-,28-,30-/m0/s1 InChIKey=UZGGSGVPDQTMCA-YYNHRMGXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
6