Back to search

Peptide record

TPDB46926

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB46926
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
MEGAQEAQGD
Physicochemical Analysis
C39H62N12O19S1
RNCHILKFPSTWYV
AEQG
1035.05
2.94
0
3
3
-3
5.88
-1.280
20.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
1
D
0
C
2
E
2
Q
2
G
0
H
0
I
0
L
0
K
1
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 0 E: 2 Q: 2 G: 2 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C39H62N12O19S1
1035.05
2.94
-3
5.88
-1.280
1035.0422
1034.3960
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
15.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Zhao Y. H., Li B. F., Dong S. Y., Zhao X., Wang J. F., Zeng M. Y.
A novel ACE inhibitory peptide isolated from Acaudina molpadioidea hydrolysate. Peptides, 30, 1028-1033, 2009
2009
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)O InChI=1S/C39H62N12O19S/c1-17(45-27(54)15-43-36(66)21(6-10-29(56)57)50-34(64)19(40)12-13-71-3)32(62)49-22(5-9-26(42)53)38(68)51-23(7-11-30(58)59)37(67)46-18(2)33(63)48-20(4-8-25(41)52)35(65)44-16-28(55)47-24(39(69)70)14-31(60)61/h17-24H,4-16,40H2,1-3H3,(H2,41,52)(H2,42,53)(H,43,66)(H,44,65)(H,45,54)(H,46,67)(H,47,55)(H,48,63)(H,49,62)(H,50,64)(H,51,68)(H,56,57)(H,58,59)(H,60,61)(H,69,70)/t17-,18-,19-,20-,21-,22-,23-,24-/m0/s1 InChIKey: MPBVRULPSLWUEZ-OPKHLUCYSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
15.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Zhao Y. H., Li B. F., Dong S. Y., Zhao X., Wang J. F., Zeng M. Y.
A novel ACE inhibitory peptide isolated from Acaudina molpadioidea hydrolysate. Peptides, 30, 1028-1033, 2009
2009
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)O InChI=1S/C39H62N12O19S/c1-17(45-27(54)15-43-36(66)21(6-10-29(56)57)50-34(64)19(40)12-13-71-3)32(62)49-22(5-9-26(42)53)38(68)51-23(7-11-30(58)59)37(67)46-18(2)33(63)48-20(4-8-25(41)52)35(65)44-16-28(55)47-24(39(69)70)14-31(60)61/h17-24H,4-16,40H2,1-3H3,(H2,41,52)(H2,42,53)(H,43,66)(H,44,65)(H,45,54)(H,46,67)(H,47,55)(H,48,63)(H,49,62)(H,50,64)(H,51,68)(H,56,57)(H,58,59)(H,60,61)(H,69,70)/t17-,18-,19-,20-,21-,22-,23-,24-/m0/s1 InChIKey: MPBVRULPSLWUEZ-OPKHLUCYSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
10