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Peptide record

TPDB46925

ACE inhibitor ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB46925
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
EVMAGNLYPG
Physicochemical Analysis
C46H71N11O15S1
RDCQHIKFSTW
G
1050.19
3.29
0
1
5
-1
1.08
0.100
78.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
1490
141.88
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
1
E
0
Q
2
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
10
C46H71N11O15S1
1050.19
3.29
-1
1.08
0.100
1050.1839
1049.4835
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
18.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Je J.-Y., Park P.-J., Byun H.-G. Jung W.-K., Kim S.-K.
Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel, Mytilus edulis. Bioresource Technol., 96, 1624-1629, 2005
2005
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)O InChI=1S/C46H71N11O15S/c1-23(2)18-30(42(68)55-32(19-26-9-11-27(58)12-10-26)46(72)57-16-7-8-33(57)44(70)50-22-37(63)64)54-43(69)31(20-34(48)59)52-35(60)21-49-39(65)25(5)51-41(67)29(15-17-73-6)53-45(71)38(24(3)4)56-40(66)28(47)13-14-36(61)62/h9-12,23-25,28-33,38,58H,7-8,13-22,47H2,1-6H3,(H2,48,59)(H,49,65)(H,50,70)(H,51,67)(H,52,60)(H,53,71)(H,54,69)(H,55,68)(H,56,66)(H,61,62)(H,63,64)/t25-,28-,29-,30-,31-,32-,33-,38-/m0/s1 InChIKey: DBZMTNPXRLPAKO-DTRKZRJBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
18.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Je J.-Y., Park P.-J., Byun H.-G. Jung W.-K., Kim S.-K.
Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel, Mytilus edulis. Bioresource Technol., 96, 1624-1629, 2005
2005
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)O InChI=1S/C46H71N11O15S/c1-23(2)18-30(42(68)55-32(19-26-9-11-27(58)12-10-26)46(72)57-16-7-8-33(57)44(70)50-22-37(63)64)54-43(69)31(20-34(48)59)52-35(60)21-49-39(65)25(5)51-41(67)29(15-17-73-6)53-45(71)38(24(3)4)56-40(66)28(47)13-14-36(61)62/h9-12,23-25,28-33,38,58H,7-8,13-22,47H2,1-6H3,(H2,48,59)(H,49,65)(H,50,70)(H,51,67)(H,52,60)(H,53,71)(H,54,69)(H,55,68)(H,56,66)(H,61,62)(H,63,64)/t25-,28-,29-,30-,31-,32-,33-,38-/m0/s1 InChIKey: DBZMTNPXRLPAKO-DTRKZRJBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
10