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Peptide record

TPDB46924

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB46924
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
KPPETV
Physicochemical Analysis
C30H51N7O10
ARNDCQGHILMFSWY
P
669.78
6.94
1
1
1
-0
4.12
-1.183
48.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
2
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
6
C30H51N7O10
669.78
6.94
-0
4.12
-1.183
669.7648
669.3685
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
24.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
He H.-L., Chen X.-L., Sun C.-Y., Zhang Y.-Z., Zhou B.-C.
Analysis of novel angiotensin-I-converting enzyme inhibitory peptides from protease-hydrolyzed marine shrimp Acetes chinensis. J. Peptide Sci., 12, 726-733, 2006
2006
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(N)CCCCN)C(=O)N[C@@]([H])(C(C)C)C(O)=O InChI=1S/C30H51N7O10/c1-16(2)23(30(46)47)34-27(43)24(17(3)38)35-25(41)19(11-12-22(39)40)33-26(42)20-9-6-14-36(20)29(45)21-10-7-15-37(21)28(44)18(32)8-4-5-13-31/h16-21,23-24,38H,4-15,31-32H2,1-3H3,(H,33,42)(H,34,43)(H,35,41)(H,39,40)(H,46,47)/t17-,18+,19+,20+,21+,23+,24+/m1/s1 InChIKey=GHIRFPGOMSDHKI-JLKNQZHWSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
24.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
He H.-L., Chen X.-L., Sun C.-Y., Zhang Y.-Z., Zhou B.-C.
Analysis of novel angiotensin-I-converting enzyme inhibitory peptides from protease-hydrolyzed marine shrimp Acetes chinensis. J. Peptide Sci., 12, 726-733, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(N)CCCCN)C(=O)N[C@@]([H])(C(C)C)C(O)=O InChI=1S/C30H51N7O10/c1-16(2)23(30(46)47)34-27(43)24(17(3)38)35-25(41)19(11-12-22(39)40)33-26(42)20-9-6-14-36(20)29(45)21-10-7-15-37(21)28(44)18(32)8-4-5-13-31/h16-21,23-24,38H,4-15,31-32H2,1-3H3,(H,33,42)(H,34,43)(H,35,41)(H,39,40)(H,46,47)/t17-,18+,19+,20+,21+,23+,24+/m1/s1 InChIKey=GHIRFPGOMSDHKI-JLKNQZHWSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6