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Peptide record

TPDB46923

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB46923
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IFVPAF
Physicochemical Analysis
C37H52N6O7
RNDCEQGHLKMSTWY
F
692.86
6.02
0
0
5
-0
-2.22
2.417
130.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
6
C37H52N6O7
692.86
6.02
-0
-2.22
2.417
692.8427
692.3885
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
3.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
He H.-L., Chen X.-L., Sun C.-Y., Zhang Y.-Z., Zhou B.-C.
Analysis of novel angiotensin-I-converting enzyme inhibitory peptides from protease-hydrolyzed marine shrimp Acetes chinensis. J. Peptide Sci., 12, 726-733, 2006
2006
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@@]([H])(N)[C@@H](C)CC)C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C37H52N6O7/c1-6-23(4)30(38)35(47)40-27(20-25-14-9-7-10-15-25)33(45)42-31(22(2)3)36(48)43-19-13-18-29(43)34(46)39-24(5)32(44)41-28(37(49)50)21-26-16-11-8-12-17-26/h7-12,14-17,22-24,27-31H,6,13,18-21,38H2,1-5H3,(H,39,46)(H,40,47)(H,41,44)(H,42,45)(H,49,50)/t23-,24-,27-,28-,29-,30-,31-/m0/s1 InChIKey: FEBSKMOIECSPNP-AOHSAGBQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
3.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
He H.-L., Chen X.-L., Sun C.-Y., Zhang Y.-Z., Zhou B.-C.
Analysis of novel angiotensin-I-converting enzyme inhibitory peptides from protease-hydrolyzed marine shrimp Acetes chinensis. J. Peptide Sci., 12, 726-733, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@@]([H])(N)[C@@H](C)CC)C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C37H52N6O7/c1-6-23(4)30(38)35(47)40-27(20-25-14-9-7-10-15-25)33(45)42-31(22(2)3)36(48)43-19-13-18-29(43)34(46)39-24(5)32(44)41-28(37(49)50)21-26-16-11-8-12-17-26/h7-12,14-17,22-24,27-31H,6,13,18-21,38H2,1-5H3,(H,39,46)(H,40,47)(H,41,44)(H,42,45)(H,49,50)/t23-,24-,27-,28-,29-,30-,31-/m0/s1 InChIKey: FEBSKMOIECSPNP-AOHSAGBQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6