Back to search

Peptide record

TPDB46922

ACE inhibitor ACE inhibitors Antihypertensive standard
6 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB46922
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
FCVLRP
Physicochemical Analysis
C34H55N9O7S1
ANDEQGHIKMSTWY
RCLFPV
733.93
9.01
1
0
3
+1
-0.60
1.200
113.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
6
C34H55N9O7S1
733.93
9.01
+1
-0.60
1.200
733.9205
733.3933
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
12.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
He H.-L., Chen X.-L., Sun C.-Y., Zhang Y.-Z., Zhou B.-C.
Analysis of novel angiotensin-I-converting enzyme inhibitory peptides from protease-hydrolyzed marine shrimp Acetes chinensis. J. Peptide Sci., 12, 726-733, 2006
2006
Journal

Other

6
BIOPEP database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C34H55N9O7S/c1-19(2)16-24(29(45)39-23(12-8-14-38-34(36)37)32(48)43-15-9-13-26(43)33(49)50)40-31(47)27(20(3)4)42-30(46)25(18-51)41-28(44)22(35)17-21-10-6-5-7-11-21/h5-7,10-11,19-20,22-27,51H,8-9,12-18,35H2,1-4H3,(H,39,45)(H,40,47)(H,41,44)(H,42,46)(H,49,50)(H4,36,37,38)/t22-,23-,24-,25-,26-,27-/m0/s1 InChIKey: QIJYKMFKXJOOGS-QCOJBMJGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
12.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
He H.-L., Chen X.-L., Sun C.-Y., Zhang Y.-Z., Zhou B.-C.
Analysis of novel angiotensin-I-converting enzyme inhibitory peptides from protease-hydrolyzed marine shrimp Acetes chinensis. J. Peptide Sci., 12, 726-733, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C34H55N9O7S/c1-19(2)16-24(29(45)39-23(12-8-14-38-34(36)37)32(48)43-15-9-13-26(43)33(49)50)40-31(47)27(20(3)4)42-30(46)25(18-51)41-28(44)22(35)17-21-10-6-5-7-11-21/h5-7,10-11,19-20,22-27,51H,8-9,12-18,35H2,1-4H3,(H,39,45)(H,40,47)(H,41,44)(H,42,46)(H,49,50)(H4,36,37,38)/t22-,23-,24-,25-,26-,27-/m0/s1 InChIKey: QIJYKMFKXJOOGS-QCOJBMJGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
6