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Peptide record

TPDB46919

ACE Inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB46919
ACE Inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
MAIPPKK
Physicochemical Analysis
C36H65N9O8S1
RNDCEQGHLFSTWYV
KP
784.03
10.60
2
0
3
+2
2.17
-0.400
70.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
2
K
1
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 2 M: 1 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C36H65N9O8S1
784.03
10.60
+2
2.17
-0.400
784.0203
783.4662
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Miguel M., Manso M. A., López-Fandiño R., Alonso M. J., Salaices M.
Vascular effects and antihypertensive properties of κ-casein macropeptide. Int. Dairy J., 17, 1473-1477, 2007
2007
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C36H65N9O8S/c1-5-22(2)29(43-30(46)23(3)40-31(47)24(39)16-21-54-4)35(51)45-20-11-15-28(45)34(50)44-19-10-14-27(44)33(49)41-25(12-6-8-17-37)32(48)42-26(36(52)53)13-7-9-18-38/h22-29H,5-21,37-39H2,1-4H3,(H,40,47)(H,41,49)(H,42,48)(H,43,46)(H,52,53)/t22-,23-,24-,25-,26-,27-,28-,29-/m0/s1 InChIKey=VPSBOBSPUBWDAJ-PJYAFMLMSA-N Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10273) the DFBP database the MBPDB database Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3294) the DFBP database the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Miguel M., Manso M. A., López-Fandiño R., Alonso M. J., Salaices M.
Vascular effects and antihypertensive properties of κ-casein macropeptide. Int. Dairy J., 17, 1473-1477, 2007
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C36H65N9O8S/c1-5-22(2)29(43-30(46)23(3)40-31(47)24(39)16-21-54-4)35(51)45-20-11-15-28(45)34(50)44-19-10-14-27(44)33(49)41-25(12-6-8-17-37)32(48)42-26(36(52)53)13-7-9-18-38/h22-29H,5-21,37-39H2,1-4H3,(H,40,47)(H,41,49)(H,42,48)(H,43,46)(H,52,53)/t22-,23-,24-,25-,26-,27-,28-,29-/m0/s1 InChIKey=VPSBOBSPUBWDAJ-PJYAFMLMSA-N Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10273) the DFBP database the MBPDB database Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3294) the DFBP database the MBPDB database
Additional Detail Fields 1 fields
7