Back to search

Peptide record

TPDB46691

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Antiviral Bitter iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB46691
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Antiviral Bitter iDPPIV
Anti-infective peptides Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antiviral, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
RP
Physicochemical Analysis
C11H21N5O3
ANDCEQGHILKMFSTWYV
RP
271.32
11.05
1
0
0
+1
1.26
-3.050
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C11H21N5O3
271.32
11.05
+1
1.26
-3.050
271.3153
271.1640
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
180.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCN=C(N)N)N)C(=O)O InChI=1S/C11H21N5O3/c12-7(3-1-5-15-11(13)14)9(17)16-6-2-4-8(16)10(18)19/h7-8H,1-6,12H2,(H,18,19)(H4,13,14,15)/t7-,8-/m0/s1 InChIKey: LQJAALCCPOTJGB-YUMQZZPRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of the neurolysin (EC 3.4.24.16) (MEROPS ID: M03.002) according to the BIOPEP-UWM database of bioactive peptides the BRENDA database Antinociceptive activity according to the ChEMBL database the PubChem database Affinity to neurotensin receptor according to the ChEMBL database the PubChem database Antiviral peptide according to the AVPdb database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8518) Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 11) Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 419)
Evidence 2 Activity

Activity

IC50
Antihypertensive
180.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCN=C(N)N)N)C(=O)O InChI=1S/C11H21N5O3/c12-7(3-1-5-15-11(13)14)9(17)16-6-2-4-8(16)10(18)19/h7-8H,1-6,12H2,(H,18,19)(H4,13,14,15)/t7-,8-/m0/s1 InChIKey: LQJAALCCPOTJGB-YUMQZZPRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of the neurolysin (EC 3.4.24.16) (MEROPS ID: M03.002) according to the BIOPEP-UWM database of bioactive peptides the BRENDA database Antinociceptive activity according to the ChEMBL database the PubChem database Affinity to neurotensin receptor according to the ChEMBL database the PubChem database Antiviral peptide according to the AVPdb database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8518) Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 11) Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 419)
Evidence 3 Activity

Activity

IC50
iDPPIV
2240.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Production of dipeptidyl peptidase IV inhibitory peptides from defated rice bran. Food Chem., 134, 797-802
2012
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCN=C(N)N)N)C(=O)O InChI=1S/C11H21N5O3/c12-7(3-1-5-15-11(13)14)9(17)16-6-2-4-8(16)10(18)19/h7-8H,1-6,12H2,(H,18,19)(H4,13,14,15)/t7-,8-/m0/s1 InChIKey: LQJAALCCPOTJGB-YUMQZZPRSA-N Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BIOPEP database of bioactive peptides (ID 7582), the ChEMBL database the EROP-Moscow database Inhibitor of the neurolysin (EC 3.4.24.16) (MEROPS ID: M03.002) according to the BIOPEP-UWM database of bioactive peptides (ID 10171) the BRENDA database Antinociceptive activity according to the ChEMBL database the PubChem database Affinity to neurotensin receptor according to the ChEMBL database the PubChem database Antiviral peptide according to the AVPdb database Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 11) Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 419)
Additional Detail Fields 1 fields
2