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Peptide record

TPDB45823

Antiviral standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB45823
Antiviral
Anti-infective peptides
DRAVP 2.0 Peptipedia
standard
No
A 36-aa standard natural antiviral peptide sequence curated from DRAVP 2.0 and Peptipedia, with an available 3D structural model.
Sequence
GFGCPLDQMQCHNHCQSVRYRGGYCTNFLKMTCKCY
Physicochemical Analysis
C177H267N53O50S8
AEIW
C
4193.87
8.30
6
1
10
+3
2.20
-0.481
29.72
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
115.53
17
Residue Composition
number
0
A
2
R
2
N
1
D
6
C
0
E
3
Q
4
G
2
H
0
I
2
L
2
K
2
M
2
F
1
P
1
S
2
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 1 C: 6 E: 0 Q: 3 G: 4 H: 2 I: 0 L: 2 K: 2 M: 2 F: 2 P: 1 S: 1 T: 2 W: 0 Y: 3 V: 1
Chemical Descriptors
36
C177H267N53O50S8
4193.87
8.30
+3
2.20
-0.481
Evidence Records 1 records
Evidence 1 Activity

Activity

Antiviral

Source & Reference

DRAVP 2.0

Other

Like plectasin, An1a also showed inhibitory activity against dengue virus-2 (DENV2, ~10 uM 50% inhibition) and Zika virus (ZIKV, ~2 uM 50% inhibition) in Vero cells. MOA: Also like plectasin and its fusion protein, An1a significantly inhibits the NS2B–NS3 protease (Ki = 9.47 uM for DENV2 and 12.54 uM for ZIKV), which is essential for flavivirus replication. In vitro Toxicity: hemo-lytic: no hemolysis of human RBC below 20 uM. Reg7/2021