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Peptide record

TPDB45504

Antiviral standard
78 amino acids
Basic Information
3D PDB MODEL
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TPDB45504
Antiviral
Anti-infective peptides
dbAMP 3.0
standard
No
A 78-aa standard natural antiviral peptide sequence curated from dbAMP 3.0, with an available 3D structural model.
Sequence
GLINEKKVQQYLDEKLPNGVVKGALKSLVHKAAKNQNLCAFNVDTVGMCDADCKRQGKAKGVCHGTKCKCDVELSYKK
Physicochemical Analysis
C366H612N108O110S7
W
K
8509.96
9.34
17
8
26
+7
24.91
-0.510
77.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
39.42
21
Residue Composition
number
6
A
1
R
5
N
5
D
6
C
3
E
4
Q
7
G
2
H
1
I
7
L
14
K
1
M
1
F
1
P
2
S
2
T
0
W
2
Y
8
V
Amino Acid Distribution
A: 6 R: 1 N: 5 D: 5 C: 6 E: 3 Q: 4 G: 7 H: 2 I: 1 L: 7 K: 14 M: 1 F: 1 P: 1 S: 2 T: 2 W: 0 Y: 2 V: 8
Chemical Descriptors
78
C366H612N108O110S7
8509.96
9.34
+7
24.91
-0.510
Evidence Records 1 records
Evidence 1 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
rEv37 and truncated peptides showed no cytolytic activity against bacteria (B-subtilis, S-aureus or E-coli at 20 uM). Another report: rEv37 can inhibit dengue virus type 2 (DENV-2), hepatitis C virus (HCV), Zika virus (ZIKV), and herpes simplex virus type 1 (HSV-1) infections in a dose-dependent manner at IC50 2-5 uM, not toxic to host cells ( Li et al., 2019 ).