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Peptide record

TPDB45293

ACE inhibitor Cyclo(L-Phe-Lys) or Dipeptide 6 Antihypertensive Antiparasitic Antiviral Neuropeptide Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB45293
ACE inhibitor Cyclo(L-Phe-Lys) or Dipeptide 6
Antihypertensive Antiparasitic Antiviral Neuropeptide Selfassembly
Anti-infective peptides Cardiometabolic peptides Neuroactive peptides Self-assembling and biomaterial peptides
AHTPDB AHTpin Peptipedia dbAMP 3.0 SAPdb
standard
No
A 2-aa standard natural multi-activity (Antihypertensive, Antiparasitic, Antiviral, and other sources) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FK
Physicochemical Analysis
C15H23N3O3
ARNDCEQGHILMPSTWYV
KF
293.37
10.10
1
0
1
+1
-0.14
-0.550
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C15H23N3O3
293.37
10.10
+1
-0.14
-0.550
293.3605
293.1734
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

23884374
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Hydrogel Transparent Hydrogel gel (Nanofibers)
pH: 8 - 11 solvent: Phosphate buffer (pH 6) concentration: 2% w/v
Selfassembly; Nanostructure=Hydrogel; Transparent Hydrogel gel (Nanofibers); Trigger=pH: 8 - 11; solvent: Phosphate buffer (pH 6); concentration: 2% w/v
Scanning Electron Microscopy (SEM)
Selfassembly
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
265.43 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Huang G.-J., Lu T., Chiu C., Chen H., Wu C., Lin Y., Hsieh W., Liao J., Sheu M. Lin Y.
Sweet potato storage root defensin and its tryptic hydrolysates exhibited angiotensin converting enzyme inhibitory activity in vitro. Bot. Stud., 52, 257-264, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C15H23N3O3/c16-9-5-4-8-13(15(20)21)18-14(19)12(17)10-11-6-2-1-3-7-11/h1-3,6-7,12-13H,4-5,8-10,16-17H2,(H,18,19)(H,20,21)/t12-,13-/m0/s1 InChIKey=FADYJNXDPBKVCA-STQMWFEESA-N Hypouricemic activity according to the BIOPEP-UWM database of bioactive peptides
Evidence 2 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Hydrogel Transparent Hydrogel gel (Nanofibers) Trigger=pH: 8 - 11 solvent: Phosphate buffer (pH 6) concentration: 2% w/v
Hydrogel Transparent Hydrogel gel (Nanofibers)

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 8 - 11 solvent: Phosphate buffer (pH 6) concentration: 2% w/v
Scanning Electron Microscopy (SEM)
23884374
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 8 - 11 solvent: Phosphate buffer (pH 6) concentration: 2% w/v
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
23884374
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly