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Peptide record

TPDB45045

Antiviral Neurotoxin standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB45045
Antiviral Neurotoxin
Anti-infective peptides Toxicity and safety peptides
AVPpred-BWR NTxPred2
standard
No
A 37-aa standard natural multi-activity (Antiviral and Neurotoxin) peptide sequence curated from AVPpred-BWR and NTxPred2, with an available 3D structural model.
Sequence
PDGRNAAAKAFDLITPTVRKGCCSNPACILNNPNQCG
Physicochemical Analysis
C159H261N51O51S4
EHMWY
AN
3831.37
8.31
4
2
11
+2
6.37
-0.324
63.51
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
250
6.53
13
Residue Composition
number
5
A
2
R
5
N
2
D
4
C
0
E
1
Q
3
G
0
H
2
I
2
L
2
K
0
M
1
F
4
P
1
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 2 N: 5 D: 2 C: 4 E: 0 Q: 1 G: 3 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 4 S: 1 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
37
C159H261N51O51S4
3831.37
8.31
+2
6.37
-0.324
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin inhibits mammalian alpha-3-beta-2/CHRNA3-CHRNB2 nAChR (IC(50)=9.4 nM (rat), IC(50)=8.8 nM (human)), as well as the subunit chimera alpha-6/alpha-3-beta-2-beta-3 nAChR (CHRNA6/CHRNA3-CHRNB2-CHRNB3)(IC(50)=2.1 nM (rat), IC(50)=1.7 nM (human)). Binds to rat alpha-6/alpha-3-beta-2-beta-3 more rapidly than to alpha-3-beta-2, and dissociates more rapidly from alpha-3-beta-2 than from alpha-6/alpha-3-beta-2-beta-3. {ECO:0000269|PubMed:34008858}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus betulinus (Beech cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin inhibits mammalian alpha-3-beta-2/CHRNA3-CHRNB2 nAChR (IC(50)=9.4 nM (rat), IC(50)=8.8 nM (human)), as well as the subunit chimera alpha-6/alpha-3-beta-2-beta-3 nAChR (CHRNA6/CHRNA3-CHRNB2-CHRNB3)(IC(50)=2.1 nM (rat), IC(50)=1.7 nM (human)).
Conotoxin Bt1.8
cone snail
Conotoxin A superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Conotoxin Bt1.8
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail