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Peptide record

TPDB44900

gH625Cys Antiviral Blood-Brain Barrier standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB44900
gH625Cys
Antiviral Blood-Brain Barrier
Anti-infective peptides Delivery and barrier-penetrating peptides
AI4AVP Peptipedia B3Pred BBPpredict
standard
No
A 20-aa standard natural multi-activity (Antiviral and Blood-Brain Barrier) peptide sequence curated from AI4AVP, Peptipedia, B3Pred, and other sources, with an available 3D structural model.
C-terminal: Cys-CONH2 group is attached at C-terminal N-terminal: Acetylaed at N-terminal
Sequence
HGLASTLTRWAHYNALIRAF
Physicochemical Analysis
C106H160N32O26
DCEQKMPV
A
2298.64
11.16
4
0
11
+2
-2.21
0.110
98.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
6990
304.09
5
Residue Composition
number
4
A
2
R
1
N
0
D
0
C
0
E
0
Q
1
G
2
H
1
I
3
L
0
K
0
M
1
F
0
P
1
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 1 L: 3 K: 0 M: 0 F: 1 P: 0 S: 1 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
20
C106H160N32O26
2298.64
11.16
+2
-2.21
0.110
Cys-CONH2 group is attached at C-terminal
Linear
Acetylaed at N-terminal
Similarity
HisGlyLeuAlaSerThrLeuThrArgTrpAlaHisTyrAsnAlaLeuIleArgAlaPhe
N[C@@]([H])(CC1=CN=C-N1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

BMECs

Assay & Model

5 micromolar
Fluorescence microscopy
Liposomes preparations were non-toxic for the endothelial cells and improves the transfer of liposom
Origin/Source
Fluorescence microscopy
gH625 ameliorates the efficiency of liposomes to deliver. PACAP

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
gH625-liposomes represent a promising strategy to deliver therapeutic agents to CNS and to provide a
Comined with liposome
Additional Detail Fields 1 fields
Intravenous