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Peptide record

TPDB43340

Antifungal Antiviral standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB43340
Antifungal Antiviral
Anti-infective peptides
Antifungipept AI4AVP dbAMP 3.0 DRAMP DRAVP 2.0 Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antifungal and Antiviral) peptide sequence curated from Antifungipept, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
SNASVWECCSTGSWVPFTCC
Physicochemical Analysis
C92H131N23O30S4
RDQHILKMY
CS
2167.43
3.29
0
1
6
-1
-2.12
0.380
34.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
11250
519.05
11
Residue Composition
number
1
A
0
R
1
N
0
D
4
C
1
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
1
P
4
S
2
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 4 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 4 T: 2 W: 2 Y: 0 V: 2
Chemical Descriptors
20
C92H131N23O30S4
2167.43
3.29
-1
-2.12
0.380
Evidence Records 2 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

DRAMP Antifungipept

Other

It inhibited HIV-1 (IC50 1.7 uM), HIV-2 (IC50 1.9 uM), HSV-1 (IC50 0.6 uM), HSV-2 (IC50 0.3 uM). labyrinthopeptins A1, the prototype congeners of carbacyclic lanthipeptides, inhibits the proliferation of diverse enveloped viruses, including dengue virus DENV-2 (IC50 0.55 uM), Zika virus (ZIKV, IC50 0.51-0.99 uM), West Nile virus (WNV IC50 0.2 uM), hepatitis C virus (HCV IC50 1.1 uM), chikungunya virus (CHIKV, IC50 2.2 uM), Kaposi’s sarcoma-associated herpesvirus, cytomegalovirus, and herpes simplex virus, in the low micromolar to nanomolar range ( Hans Prochnow et al., 2020 ). Updated 7/2021
Evidence 2 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It inhibited HIV-1 (IC50 1.7 uM), HIV-2 (IC50 1.9 uM), HSV-1 (IC50 0.6 uM), HSV-2 (IC50 0.3 uM). labyrinthopeptins A1, the prototype congeners of carbacyclic lanthipeptides, inhibits the proliferation of diverse enveloped viruses, including dengue virus DENV-2 (IC50 0.55 uM), Zika virus (ZIKV, IC50 0.51-0.99 uM), West Nile virus (WNV IC50 0.2 uM), hepatitis C virus (HCV IC50 1.1 uM), chikungunya virus (CHIKV, IC50 2.2 uM), Kaposi’s sarcoma-associated herpesvirus, cytomegalovirus, and herpes simplex virus, in the low micromolar to nanomolar range ( Hans Prochnow et al., 2020 ). Updated 7/2021