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Peptide record

TPDB43339

Antifungal Antiviral standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB43339
Antifungal Antiviral
Anti-infective peptides
Antifungipept AI4AVP dbAMP 3.0 DRAMP DRAVP 2.0 Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antifungal and Antiviral) peptide sequence curated from Antifungipept, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
SDWSLWECCSTGSLFACC
Physicochemical Analysis
C85H120N20O28S4
RNQHIKMPYV
CS
1998.24
3.01
0
2
6
-2
-3.16
0.506
48.89
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
11250
562.99
9
Residue Composition
number
1
A
0
R
0
N
1
D
4
C
1
E
0
Q
1
G
0
H
0
I
2
L
0
K
0
M
1
F
0
P
4
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 4 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 4 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
18
C85H120N20O28S4
1998.24
3.01
-2
-3.16
0.506
Evidence Records 2 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

DRAMP Antifungipept

Other

Bioactivity assays revealed that labyrinthopeptin A2 has an excellent efficacy against neuropathic pain in an in vivo mouse model (ED50 = 50 mg/kg). labyrinthopeptins A2, the prototype congeners of carbacyclic lanthipeptides, inhibits the proliferation of diverse enveloped viruses, including dengue virus, Zika virus (ZIKV), West Nile virus (WNV), hepatitis C virus (HCV), chikungunya virus, Kaposi’s sarcoma-associated herpesvirus, cytomegalovirus, and herpes simplex virus, in the low micromolar to nanomolar range ( Hans Prochnow et al., 2020 ). Antinociceptive Activity: effective against nociceptive pain ( Meindl et al., 2010 ).
Evidence 2 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Bioactivity assays revealed that labyrinthopeptin A2 has an excellent efficacy against neuropathic pain in an in vivo mouse model (ED50 = 50 mg/kg). labyrinthopeptins A2, the prototype congeners of carbacyclic lanthipeptides, inhibits the proliferation of diverse enveloped viruses, including dengue virus, Zika virus (ZIKV), West Nile virus (WNV), hepatitis C virus (HCV), chikungunya virus, Kaposi’s sarcoma-associated herpesvirus, cytomegalovirus, and herpes simplex virus, in the low micromolar to nanomolar range ( Hans Prochnow et al., 2020 ). Antinociceptive Activity: effective against nociceptive pain ( Meindl et al., 2010 ).